{"id":"dc95b1ad-2e1a-5656-a334-91bd7080db53","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-cud-ferroportin-boundary","predicate":"deficiency_has_complex_effects_on","statement":"Dietary copper deficiency caused little ferroportin mRNA change; protein responses varied and did not account for the anemia across the rodent models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"043d2ae4-8656-5ee4-9412-b02c7d153b4d","mechanism_event_label":"There is no single demonstrated switch that destroys every iron exporter when copper falls.","subject":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"object":{"id":"8b5156ee-65e8-5251-a149-45ca58f77e49","slug":"rodent-ferroportin-abundance","display_name":"Rodent tissue ferroportin protein abundance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"043d2ae4-8656-5ee4-9412-b02c7d153b4d","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-cud-ferroportin-boundary-event","event_type":"biochemical_relationship","label":"There is no single demonstrated switch that destroys every iron exporter when copper falls.","description":"Dietary copper deficiency caused little ferroportin mRNA change; protein responses varied and did not account for the anemia across the rodent models.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8b5156ee-65e8-5251-a149-45ca58f77e49","slug":"rodent-ferroportin-abundance","display_name":"Rodent tissue ferroportin protein abundance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/22294464.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"008de3f1f584a29a0ce082e6423042ed21585064b2dc900802103fc00b3fee8e\", \"start_char\": 0, \"end_char\": 1578, \"text_sha256\": \"008de3f1f584a29a0ce082e6423042ed21585064b2dc900802103fc00b3fee8e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary copper-deficient rat and mouse tissue comparisons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Dietary copper depletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tissue ferroportin responses were complex and did not explain copper-deficiency anemia. Do not generalize genetic GPI-ceruloplasmin absence into universal ferroportin destruction during nutritional copper deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat and mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"There is no single demonstrated switch that destroys every iron exporter when copper falls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p22294464] Copper deficiency has minimal impact on ferroportin expression or function. (2012). https://pubmed.ncbi.nlm.nih.gov/22294464/ DOI: 10.1007/s10534-012-9521-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver, spleen and intestinal iron-related tissues","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"44261be4-3e52-5381-a37f-8eed7f40c039","evidence_kind":"source_excerpt","locator":"Lines 884-895","start_line":884,"end_line":895,"excerpt":"### copper-cud-ferroportin-boundary\nDietary copper deficiency caused little ferroportin mRNA change; protein responses varied and did not account for the anemia across the rodent models.\nCondition category: nutrient_deficiency\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: There is no single demonstrated switch that destroys every iron exporter when copper falls.\norganism: Rat and mouse\ntissue_or_cell_type: Liver, spleen and intestinal iron-related tissues\nexperimental_model: Dietary copper-deficient rat and mouse tissue comparisons\nlimitations: Tissue ferroportin responses were complex and did not explain copper-deficiency anemia. Do not generalize genetic GPI-ceruloplasmin absence into universal ferroportin destruction during nutritional copper deficiency.\nexposure: Dietary copper depletion\nevidence_span: {\"source_cache\": \"artifacts/copper-research/22294464.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"008de3f1f584a29a0ce082e6423042ed21585064b2dc900802103fc00b3fee8e\", \"start_char\": 0, \"end_char\": 1578, \"text_sha256\": \"008de3f1f584a29a0ce082e6423042ed21585064b2dc900802103fc00b3fee8e\"}\n[copper-p22294464] Copper deficiency has minimal impact on ferroportin expression or function. (2012). https://pubmed.ncbi.nlm.nih.gov/22294464/ DOI: 10.1007/s10534-012-9521-2","model_system":"Dietary copper-deficient rat and mouse tissue comparisons","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p22294464] Copper deficiency has minimal impact on ferroportin expression or function. (2012). https://pubmed.ncbi.nlm.nih.gov/22294464/ DOI: 10.1007/s10534-012-9521-2","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"84b0f62b2dae6835fa26902be87625c003c6c707492d3007e8f9d15420669008","revision_id":"d7e35b8b-3f77-56d9-90b5-5f542c63f321","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}