Component
Rifaximin
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Five days of rifaximin reduced colonic naringenin permeability and lowered luminal 4-hydroxyhippuric and hippuric acids in mice.
Experimental context and source evidence
- dose
- Rifaximin 50 mg/kg/day for 5 days; naringenin 3.5 micrograms/mL
- duration
- 5 days plus 60-minute perfusion
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Mice undergoing colonic perfusion
- limitations
- The antibiotic changes multiple microbial and host processes; this does not support using rifaximin to control naringenin exposure.
- nutrient_topic
- Naringenin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Naringenin
- organism
- Mice undergoing colonic perfusion
- plain_language
- Five days of rifaximin reduced colonic naringenin permeability and lowered luminal 4-hydroxyhippuric and hippuric acids in mice.
- primary_references
- High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism. (2015). https://pubmed.ncbi.nlm.nih.gov/26083965/ DOI: 10.1017/S0007114515001671
- route
- Oral pretreatment and in-situ perfusion
- tissue
- Antibiotic perturbation of absorption and microbial products
Naringenin: mechanism of action and interactions (2026-09-20) · lines 55–64
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Mice undergoing colonic perfusion · source_derived_draft · unverified_draft
## naringenin-rifaximin-effect Five days of rifaximin reduced colonic naringenin permeability and lowered luminal 4-hydroxyhippuric and hippuric acids in mice. Model/species: Mice undergoing colonic perfusion Tissue/system: Antibiotic perturbation of absorption and microbial products Exposure: Rifaximin 50 mg/kg/day for 5 days; naringenin 3.5 micrograms/mL Route: Oral pretreatment and in-situ perfusion Duration: 5 days plus 60-minute perfusion Limits: The antibiotic changes multiple microbial and host processes; this does not support using rifaximin to control naringenin exposure. Primary reference: High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism. (2015). https://pubmed.ncbi.nlm.nih.gov/26083965/ DOI: 10.1017/S0007114515001671 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.