Component
Resveratrol 4′-O-sulfate
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Adding a sulfatase inhibitor reduced intracellular resveratrol and abrogated monosulfate-induced autophagy and senescence in human colorectal cancer cells.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Human colorectal cancer cultures.
- limitations
- Senescence induction is not senolytic removal; not established prevention or treatment in people.
- nutrient_topic
- Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Resveratrol
- plain_language
- Blocking local release weakened the cell response.
- primary_references
- Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24089405/ · DOI 10.1126/scitranslmed.3005870
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19) · lines 102–108
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human colorectal cancer cultures. · source_derived_draft · unverified_draft
## resveratrol-sulfatase-block Blocking local release weakened the cell response. Adding a sulfatase inhibitor reduced intracellular resveratrol and abrogated monosulfate-induced autophagy and senescence in human colorectal cancer cells. Model: Human colorectal cancer cultures. Limitations: Senescence induction is not senolytic removal; not established prevention or treatment in people. Evidence access: Primary abstract Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24089405/ · DOI 10.1126/scitranslmed.3005870
Complete structured claim and evidenceResveratrol monosulfates were converted to parent resveratrol in human colorectal cells; sulfate hydrolysis also liberated parent after metabolite dosing in mice.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human cell experiments, human exposure measurements and separate mouse pharmacokinetics.
- limitations
- Cell uptake was transporter-dependent; abstract does not identify all responsible transporter/isoenzyme identities.
- nutrient_topic
- Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Resveratrol
- plain_language
- Conjugation can create a reservoir, not simply inactivate everything.
- primary_references
- Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24089405/ · DOI 10.1126/scitranslmed.3005870
Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19) · lines 94–100
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human cell experiments, human exposure measurements and separate mouse pharmacokinetics. · source_derived_draft · unverified_draft
## resveratrol-sulfate-reservoir Conjugation can create a reservoir, not simply inactivate everything. Resveratrol monosulfates were converted to parent resveratrol in human colorectal cells; sulfate hydrolysis also liberated parent after metabolite dosing in mice. Model: Human cell experiments, human exposure measurements and separate mouse pharmacokinetics. Limitations: Cell uptake was transporter-dependent; abstract does not identify all responsible transporter/isoenzyme identities. Evidence access: Primary abstract Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24089405/ · DOI 10.1126/scitranslmed.3005870
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.