{"id":"6c1bd687-7983-538e-ba5c-4b620ee81b3c","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-sulfate-reservoir","predicate":"can_regenerate","statement":"Resveratrol monosulfates were converted to parent resveratrol in human colorectal cells; sulfate hydrolysis also liberated parent after metabolite dosing in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"26651d61-7042-58ef-8aec-d372130e9498","mechanism_event_label":"Conjugation can create a reservoir, not simply inactivate everything.","subject":{"id":"08140d84-7366-5b7f-b3a3-e0ec20f6ae2e","slug":"resveratrol-3-o-sulfate","display_name":"Resveratrol 3-O-sulfate","entity_type_key":"small_molecule"},"object":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"26651d61-7042-58ef-8aec-d372130e9498","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-sulfate-reservoir-event","event_type":"observed_relationship","label":"Conjugation can create a reservoir, not simply inactivate everything.","description":"Resveratrol monosulfates were converted to parent resveratrol in human colorectal cells; 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abstract does not identify all responsible transporter/isoenzyme identities.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Conjugation can create a reservoir, not simply inactivate everything.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24089405/ · DOI 10.1126/scitranslmed.3005870","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"90cc5ecf-8d09-59ee-82cb-0309e8eee9b0","evidence_kind":"source_excerpt","locator":"Lines 94-100","start_line":94,"end_line":100,"excerpt":"## resveratrol-sulfate-reservoir\nConjugation can create a reservoir, not simply inactivate everything.\nResveratrol monosulfates were converted to parent resveratrol in human colorectal cells; sulfate hydrolysis also liberated parent after metabolite dosing in mice.\nModel: Human cell experiments, human exposure measurements and separate mouse pharmacokinetics.\nLimitations: Cell uptake was transporter-dependent; abstract does not identify all responsible transporter/isoenzyme identities.\nEvidence access: Primary abstract\nSulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24089405/ · DOI 10.1126/scitranslmed.3005870","model_system":"Human cell experiments, human exposure measurements and separate mouse pharmacokinetics.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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