{"id":"2808b5c1-840a-54ba-a75f-5c615ff06034","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-sulfatase-block","predicate":"inhibition_reduces","statement":"Adding a sulfatase inhibitor reduced intracellular resveratrol and abrogated monosulfate-induced autophagy and senescence in human colorectal cancer cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a939f8f1-4a39-56d5-ab06-fc0b321f8cdd","mechanism_event_label":"Blocking local release weakened the cell response.","subject":{"id":"8e67b36c-f87a-5a9e-bcd7-1adb1b9d8a28","slug":"human-colorectal-resveratrol-sulfate-hydrolysis","display_name":"Resveratrol sulfate hydrolysis in human colorectal cells","entity_type_key":"cellular_process"},"object":{"id":"a6879624-aabb-5c84-b852-d812ca855610","slug":"human-colorectal-resveratrol-sulfate-cell-response","display_name":"Autophagy and senescence after resveratrol sulfates in human colorectal cancer cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a939f8f1-4a39-56d5-ab06-fc0b321f8cdd","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-sulfatase-block-event","event_type":"observed_relationship","label":"Blocking local release weakened the cell response.","description":"Adding a sulfatase inhibitor reduced intracellular resveratrol and abrogated monosulfate-induced autophagy and senescence in human colorectal cancer cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e67b36c-f87a-5a9e-bcd7-1adb1b9d8a28","slug":"human-colorectal-resveratrol-sulfate-hydrolysis","display_name":"Resveratrol sulfate hydrolysis in human colorectal cells","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a6879624-aabb-5c84-b852-d812ca855610","slug":"human-colorectal-resveratrol-sulfate-cell-response","display_name":"Autophagy and senescence after resveratrol sulfates in human colorectal cancer cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"08140d84-7366-5b7f-b3a3-e0ec20f6ae2e","slug":"resveratrol-3-o-sulfate","display_name":"Resveratrol 3-O-sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"39c8cc3c-3013-5ebe-b739-602ac136c8ee","slug":"resveratrol-4-prime-o-sulfate","display_name":"Resveratrol 4′-O-sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human colorectal cancer cultures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Senescence induction is not senolytic removal; not established prevention or treatment in people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Blocking local release weakened the cell response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24089405/ · DOI 10.1126/scitranslmed.3005870","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"14535116-1f23-5d89-ba2d-eafcdb0e0d95","evidence_kind":"source_excerpt","locator":"Lines 102-108","start_line":102,"end_line":108,"excerpt":"## resveratrol-sulfatase-block\nBlocking local release weakened the cell response.\nAdding a sulfatase inhibitor reduced intracellular resveratrol and abrogated monosulfate-induced autophagy and senescence in human colorectal cancer cells.\nModel: Human colorectal cancer cultures.\nLimitations: Senescence induction is not senolytic removal; not established prevention or treatment in people.\nEvidence access: Primary abstract\nSulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24089405/ · DOI 10.1126/scitranslmed.3005870","model_system":"Human colorectal cancer cultures.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}