Component

Apical citrulline uptake in renal proximal tubular cells

Apical citrulline uptake in renal proximal tubular cells. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Silencing SLC6A19 reduced citrulline uptake in human HK-2 renal cells.

    Human neutral amino acid transporter B0AT1 / SLC6A19 → Apical citrulline uptake in renal proximal tubular cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/citrulline-research/19322909.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece", "start_char": 0, "end_char": 1531, "text_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece"}
    experimental_model
    Apical transport kinetics and transporter knockdown
    exposure
    Citrulline uptake on permeable supports; SLC6A19 or SLC7A9 silencing
    limitations
    Renal evidence must not be relabeled as a demonstrated human intestinal transport mechanism.
    nutrient_topic
    Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
    organism
    Human HK-2 cells; rat cultures studied separately
    plain_language
    A neutral-amino-acid transporter contributes to kidney uptake.
    primary_references
    [citrulline-p19322909] Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19322909/ DOI: 10.1002/bdd.653
    tissue_or_cell_type
    Renal proximal tubular epithelium

    Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 398–409

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Apical transport kinetics and transporter knockdown · source_derived_draft · unverified_draft

    ### citrulline-renal-b0at1 Silencing SLC6A19 reduced citrulline uptake in human HK-2 renal cells. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: A neutral-amino-acid transporter contributes to kidney uptake. organism: Human HK-2 cells; rat cultures studied separately tissue_or_cell_type: Renal proximal tubular epithelium experimental_model: Apical transport kinetics and transporter knockdown limitations: Renal evidence must not be relabeled as a demonstrated human intestinal transport mechanism. exposure: Citrulline uptake on permeable supports; SLC6A19 or SLC7A9 silencing evidence_span: {"source_cache": "artifacts/citrulline-research/19322909.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece", "start_char": 0, "end_char": 1531, "text_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece"} [citrulline-p19322909] Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19322909/ DOI: 10.1002/bdd.653
    Complete structured claim and evidence

  2. Silencing SLC7A9 also reduced citrulline uptake in HK-2 cells.

    b0,+AT / SLC7A9 → Apical citrulline uptake in renal proximal tubular cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/citrulline-research/19322909.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece", "start_char": 0, "end_char": 1531, "text_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece"}
    experimental_model
    Apical transport kinetics and transporter knockdown
    exposure
    Citrulline uptake on permeable supports; SLC6A19 or SLC7A9 silencing
    limitations
    Renal evidence must not be relabeled as a demonstrated human intestinal transport mechanism.
    nutrient_topic
    Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
    organism
    Human HK-2 cells; rat cultures studied separately
    plain_language
    A separate transporter contributes to the measured uptake.
    primary_references
    [citrulline-p19322909] Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19322909/ DOI: 10.1002/bdd.653
    tissue_or_cell_type
    Renal proximal tubular epithelium

    Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 411–422

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Apical transport kinetics and transporter knockdown · source_derived_draft · unverified_draft

    ### citrulline-renal-b0plus Silencing SLC7A9 also reduced citrulline uptake in HK-2 cells. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: A separate transporter contributes to the measured uptake. organism: Human HK-2 cells; rat cultures studied separately tissue_or_cell_type: Renal proximal tubular epithelium experimental_model: Apical transport kinetics and transporter knockdown limitations: Renal evidence must not be relabeled as a demonstrated human intestinal transport mechanism. exposure: Citrulline uptake on permeable supports; SLC6A19 or SLC7A9 silencing evidence_span: {"source_cache": "artifacts/citrulline-research/19322909.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece", "start_char": 0, "end_char": 1531, "text_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece"} [citrulline-p19322909] Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19322909/ DOI: 10.1002/bdd.653
    Complete structured claim and evidence

  3. HK-2 citrulline uptake included two sodium-dependent saturable components and one sodium-independent component.

    Sodium ion → Apical citrulline uptake in renal proximal tubular cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/citrulline-research/19322909.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece", "start_char": 0, "end_char": 1531, "text_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece"}
    experimental_model
    Apical transport kinetics and transporter knockdown
    exposure
    Citrulline uptake on permeable supports; SLC6A19 or SLC7A9 silencing
    limitations
    Renal evidence must not be relabeled as a demonstrated human intestinal transport mechanism.
    nutrient_topic
    Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
    organism
    Human HK-2 cells; rat cultures studied separately
    plain_language
    Sodium dependence applies to part of the transport system, not every citrulline transporter.
    primary_references
    [citrulline-p19322909] Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19322909/ DOI: 10.1002/bdd.653
    tissue_or_cell_type
    Renal proximal tubular epithelium

    Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 424–435

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Apical transport kinetics and transporter knockdown · source_derived_draft · unverified_draft

    ### citrulline-renal-sodium HK-2 citrulline uptake included two sodium-dependent saturable components and one sodium-independent component. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Sodium dependence applies to part of the transport system, not every citrulline transporter. organism: Human HK-2 cells; rat cultures studied separately tissue_or_cell_type: Renal proximal tubular epithelium experimental_model: Apical transport kinetics and transporter knockdown limitations: Renal evidence must not be relabeled as a demonstrated human intestinal transport mechanism. exposure: Citrulline uptake on permeable supports; SLC6A19 or SLC7A9 silencing evidence_span: {"source_cache": "artifacts/citrulline-research/19322909.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece", "start_char": 0, "end_char": 1531, "text_sha256": "f466fcced77ee9fe7a97f010112a035332d513382d13e6187d10bc02be152ece"} [citrulline-p19322909] Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. (2009). https://pubmed.ncbi.nlm.nih.gov/19322909/ DOI: 10.1002/bdd.653
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards