Component
Calcium oxalate stone recurrence
Process or measured study endpoint, not a chemical species; outcome definition is retained in claim context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A normal-calcium diet with less animal protein and salt reduced stone recurrence compared with a low-calcium diet.
Experimental context and source evidence
- experimental_model
- 120 hypercalciuric male recurrent stone formers; five-year randomized comparison.
- exposure
- Recurrences 12/60 versus 23/60; RR 0.49, 95% CI 0.24-0.98. Calcium 30 versus 10 mmol/day; intervention also reduced animal protein and salt.
- limitations
- Multiple dietary components changed together, preventing isolated calcium attribution.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- Restricting calcium was not the better strategy in this particular dietary trial.
- primary_references
- [cal-clin-borghi2002] Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria (2002). https://pubmed.ncbi.nlm.nih.gov/11784873/ DOI: 10.1056/NEJMoa010369
- tissue_or_cell_type
- Human clinical or absorption endpoint
Calcium: mechanism-first literature curation (2026-09-17) · lines 1235–1245
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 120 hypercalciuric male recurrent stone formers; five-year randomized comparison. · source_derived_draft · unverified_draft
### cal-borghi-stone-recurrence A normal-calcium diet with less animal protein and salt reduced stone recurrence compared with a low-calcium diet. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Restricting calcium was not the better strategy in this particular dietary trial. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: 120 hypercalciuric male recurrent stone formers; five-year randomized comparison. limitations: Multiple dietary components changed together, preventing isolated calcium attribution. exposure: Recurrences 12/60 versus 23/60; RR 0.49, 95% CI 0.24-0.98. Calcium 30 versus 10 mmol/day; intervention also reduced animal protein and salt. [cal-clin-borghi2002] Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria (2002). https://pubmed.ncbi.nlm.nih.gov/11784873/ DOI: 10.1056/NEJMoa010369
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.