Component
Retina-directed RDH10 loss
Six3-Cre-mediated Rdh10 deletion in the mouse neural retina; distinguish from RPE-specific deletion.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Six3-Cre-directed Rdh10 deletion left mouse cone dark adaptation comparable to controls after pigment bleaching in isolated retinas and intact eyes.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Figure 7A-B; Results: retina RDH10 and dark adaptation
- experimental_model
- Six3-Cre Rdh10-flox homozygotes on Gnat1-null background
- exposure
- Approximately 90% pigment bleach; Figure 7A-B.
- limitations
- Müller-specific mutants were not separately tested for dark adaptation; whole-retina results must not be relabeled as that experiment.
- nutrient
- Vitamin A · Vitamin A
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- Removing neural-retinal RDH10 did not impair the tested cone recovery.
- primary_references
- [vav-xue2017] The role of retinol dehydrogenase 10 in the cone visual cycle. (2017). https://pubmed.ncbi.nlm.nih.gov/28539612/ DOI: 10.1038/s41598-017-02549-8
- tissue_or_cell_type
- neural retina; intact-eye and transretinal ERG
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 648–661
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six3-Cre Rdh10-flox homozygotes on Gnat1-null background · source_derived_draft · unverified_draft
### vae-rdh10-retinal-deletion-recovery Six3-Cre-directed Rdh10 deletion left mouse cone dark adaptation comparable to controls after pigment bleaching in isolated retinas and intact eyes. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing neural-retinal RDH10 did not impair the tested cone recovery. organism: Mus musculus tissue_or_cell_type: neural retina; intact-eye and transretinal ERG experimental_model: Six3-Cre Rdh10-flox homozygotes on Gnat1-null background limitations: Müller-specific mutants were not separately tested for dark adaptation; whole-retina results must not be relabeled as that experiment. exposure: Approximately 90% pigment bleach; Figure 7A-B. cross_nutrient: false evidence_location: Figure 7A-B; Results: retina RDH10 and dark adaptation nutrient: Vitamin A [vav-xue2017] The role of retinol dehydrogenase 10 in the cone visual cycle. (2017). https://pubmed.ncbi.nlm.nih.gov/28539612/ DOI: 10.1038/s41598-017-02549-8
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.