Component
RBP4 loss
Rbp4-knockout state in the cited mice.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Circulating retinol became undetectable after one week of vitamin A-deficient feeding in adult Rbp4-null mice.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_location
- Abstract
- experimental_model
- Rbp4-knockout mice on vitamin A-sufficient and deficient diets.
- exposure
- Adult Rbp4-null mice placed on vitamin A-deficient diet.
- limitations
- Assay undetectability is model-specific, not a universal cellular threshold.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- outcome
- Circulating retinol became undetectable after one week of vitamin A-deficient feeding in adult Rbp4-null mice.
- plain_language
- Dietary supply could no longer compensate for lost transport from stores.
- primary_references
- [va-quadro-1999] Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein (1999). https://pmc.ncbi.nlm.nih.gov/articles/PMC1171537/ DOI: 10.1093/emboj/18.17.4633
- tissue_or_cell_type
- Serum
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 388–400
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rbp4-knockout mice on vitamin A-sufficient and deficient diets. · source_derived_draft · unverified_draft
### va-rbp4-dietary-withdrawal Circulating retinol became undetectable after one week of vitamin A-deficient feeding in adult Rbp4-null mice. Condition category: nutrient_deficiency nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Dietary supply could no longer compensate for lost transport from stores. organism: Mus musculus tissue_or_cell_type: Serum experimental_model: Rbp4-knockout mice on vitamin A-sufficient and deficient diets. limitations: Assay undetectability is model-specific, not a universal cellular threshold. exposure: Adult Rbp4-null mice placed on vitamin A-deficient diet. outcome: Circulating retinol became undetectable after one week of vitamin A-deficient feeding in adult Rbp4-null mice. evidence_location: Abstract [va-quadro-1999] Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein (1999). https://pmc.ncbi.nlm.nih.gov/articles/PMC1171537/ DOI: 10.1093/emboj/18.17.4633
Complete structured claim and evidenceRbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- Abstract
- experimental_model
- Rbp4-knockout mice on vitamin A-sufficient and deficient diets.
- exposure
- Rbp4 knockout under sufficient and deficient feeding.
- limitations
- Alternative delivery operates with adequate intake; RBP4 is not the sole tissue supply route.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- outcome
- Rbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally.
- plain_language
- Stored vitamin A can remain inaccessible when its transport protein is absent.
- primary_references
- [va-quadro-1999] Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein (1999). https://pmc.ncbi.nlm.nih.gov/articles/PMC1171537/ DOI: 10.1093/emboj/18.17.4633
- tissue_or_cell_type
- Liver and circulation
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 374–386
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rbp4-knockout mice on vitamin A-sufficient and deficient diets. · source_derived_draft · unverified_draft
### va-rbp4-store-mobilization Rbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Stored vitamin A can remain inaccessible when its transport protein is absent. organism: Mus musculus tissue_or_cell_type: Liver and circulation experimental_model: Rbp4-knockout mice on vitamin A-sufficient and deficient diets. limitations: Alternative delivery operates with adequate intake; RBP4 is not the sole tissue supply route. exposure: Rbp4 knockout under sufficient and deficient feeding. outcome: Rbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally. evidence_location: Abstract [va-quadro-1999] Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein (1999). https://pmc.ncbi.nlm.nih.gov/articles/PMC1171537/ DOI: 10.1093/emboj/18.17.4633
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.