{"id":"870b54d0-c3a7-59bc-8e5a-c5a0ffd1cd8f","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-rbp4-dietary-withdrawal","predicate":"maintains","statement":"Circulating retinol became undetectable after one week of vitamin A-deficient feeding in adult Rbp4-null mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"5a5ea5ca-250b-5760-a6ca-c784fa748c53","mechanism_event_label":"Dietary supply could no longer compensate for lost transport from stores.","subject":{"id":"2166313e-8877-585f-8594-c8813793c5ed","slug":"rbp4","display_name":"Retinol-binding protein 4 / RBP4","entity_type_key":"protein"},"object":{"id":"4f9db882-aaee-5149-820f-0cfcb9e63931","slug":"serum-retinol-concentration","display_name":"Serum retinol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5a5ea5ca-250b-5760-a6ca-c784fa748c53","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-rbp4-dietary-withdrawal-event","event_type":"biochemical_relationship","label":"Dietary supply could no longer compensate for lost transport from stores.","description":"Circulating retinol became undetectable after one week of vitamin A-deficient feeding in adult Rbp4-null mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f52dd3f8-dd93-50a8-9f14-be0966a32e41","slug":"rbp4-loss","display_name":"RBP4 loss","entity_type_key":"protein_state"},"role":"experimental-machinery-state","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2166313e-8877-585f-8594-c8813793c5ed","slug":"rbp4","display_name":"Retinol-binding protein 4 / RBP4","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4f9db882-aaee-5149-820f-0cfcb9e63931","slug":"serum-retinol-concentration","display_name":"Serum retinol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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