{"id":"828264b5-0cf2-5d68-a2bb-c30ec4e78dee","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-rbp4-store-mobilization","predicate":"enables","statement":"Rbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ec357a45-d5a3-5076-b451-b2ac6d1a0b3a","mechanism_event_label":"Stored vitamin A can remain inaccessible when its transport protein is absent.","subject":{"id":"2166313e-8877-585f-8594-c8813793c5ed","slug":"rbp4","display_name":"Retinol-binding protein 4 / RBP4","entity_type_key":"protein"},"object":{"id":"c977697b-a405-52dc-b54c-f28b2c5ae0e8","slug":"hepatic-retinol-mobilization","display_name":"Hepatic retinol mobilization","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ec357a45-d5a3-5076-b451-b2ac6d1a0b3a","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-rbp4-store-mobilization-event","event_type":"biochemical_relationship","label":"Stored vitamin A can remain inaccessible when its transport protein is absent.","description":"Rbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"transported-retinoid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f52dd3f8-dd93-50a8-9f14-be0966a32e41","slug":"rbp4-loss","display_name":"RBP4 loss","entity_type_key":"protein_state"},"role":"experimental-machinery-state","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2166313e-8877-585f-8594-c8813793c5ed","slug":"rbp4","display_name":"Retinol-binding protein 4 / RBP4","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c977697b-a405-52dc-b54c-f28b2c5ae0e8","slug":"hepatic-retinol-mobilization","display_name":"Hepatic retinol mobilization","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_location","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rbp4-knockout mice on vitamin A-sufficient and deficient diets.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Rbp4 knockout under sufficient and deficient feeding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Alternative delivery operates with adequate intake; RBP4 is not the sole tissue supply route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"outcome","value_text":"Rbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Stored vitamin A can remain inaccessible when its transport protein is absent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-quadro-1999] Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein (1999). https://pmc.ncbi.nlm.nih.gov/articles/PMC1171537/ DOI: 10.1093/emboj/18.17.4633","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver and circulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"244c8734-d966-5b14-a91f-7c5611a4bf37","evidence_kind":"source_excerpt","locator":"Lines 374-386","start_line":374,"end_line":386,"excerpt":"### va-rbp4-store-mobilization\nRbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Stored vitamin A can remain inaccessible when its transport protein is absent.\norganism: Mus musculus\ntissue_or_cell_type: Liver and circulation\nexperimental_model: Rbp4-knockout mice on vitamin A-sufficient and deficient diets.\nlimitations: Alternative delivery operates with adequate intake; RBP4 is not the sole tissue supply route.\nexposure: Rbp4 knockout under sufficient and deficient feeding.\noutcome: Rbp4-null mice acquired hepatic vitamin A stores but could not mobilize them normally.\nevidence_location: Abstract\n[va-quadro-1999] Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein (1999). https://pmc.ncbi.nlm.nih.gov/articles/PMC1171537/ DOI: 10.1093/emboj/18.17.4633","model_system":"Rbp4-knockout mice on vitamin A-sufficient and deficient diets.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-quadro-1999] Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein (1999). https://pmc.ncbi.nlm.nih.gov/articles/PMC1171537/ DOI: 10.1093/emboj/18.17.4633","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}