Component
Interphotoreceptor retinoid-binding protein / IRBP
RBP3 extracellular retinoid-binding protein.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
IRBP at at least 10 micromolar increased all-trans-retinol release from bleached isolated toad retina during dark incubation.
Experimental context and source evidence
- experimental_model
- 2-90 micromolar IRBP; 5-180-minute incubation; HPLC
- limitations
- Measures release, not the entire in vivo round trip to RPE.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Bufo marinus
- plain_language
- Extracellular IRBP helps remove retinol from the bleached retina.
- primary_references
- [qtaishat-2005] Interphotoreceptor retinoid-binding protein (IRBP) promotes the release of all-trans retinol from the isolated retina following rhodopsin bleaching illumination (2005). https://pubmed.ncbi.nlm.nih.gov/15935345/ DOI: 10.1016/j.exer.2005.03.005
- tissue_or_cell_type
- Isolated retina and extracellular medium
- transport_direction
- retina to extracellular medium
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 789–799
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 2-90 micromolar IRBP; 5-180-minute incubation; HPLC · source_derived_draft · unverified_draft
### a-vision-irbp-retinol-release IRBP at at least 10 micromolar increased all-trans-retinol release from bleached isolated toad retina during dark incubation. Condition category: normal nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Extracellular IRBP helps remove retinol from the bleached retina. organism: Bufo marinus tissue_or_cell_type: Isolated retina and extracellular medium experimental_model: 2-90 micromolar IRBP; 5-180-minute incubation; HPLC limitations: Measures release, not the entire in vivo round trip to RPE. transport_direction: retina to extracellular medium [qtaishat-2005] Interphotoreceptor retinoid-binding protein (IRBP) promotes the release of all-trans retinol from the isolated retina following rhodopsin bleaching illumination (2005). https://pubmed.ncbi.nlm.nih.gov/15935345/ DOI: 10.1016/j.exer.2005.03.005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.