Component
Curcumin-modified rat thioredoxin reductase 1
Curcumin-modified rat thioredoxin reductase 1. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The modified enzyme acquired increased NADPH oxidase activity associated with reactive oxygen species production.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/curcumin-research/15879598.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c", "start_char": 0, "end_char": 1659, "text_sha256": "be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c"}
- experimental_model
- Purified rat enzyme and separate HeLa-cell assays
- exposure
- Rat enzyme: two-hour incubation, IC50 3.6 micromolar; HeLa activity IC50 about 15 micromolar
- limitations
- Rat residue numbering Cys496/Sec497 is source-specific and must not replace numbering in other TrxR constructs. Cellular enzyme activity does not prove clinical cancer benefit.
- nutrient_topic
- Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
- organism
- Rattus norvegicus
- plain_language
- The modified protein could consume reducing power while promoting oxidation.
- primary_references
- [curcumin-p15879598] Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. (2005). https://pubmed.ncbi.nlm.nih.gov/15879598/ DOI: 10.1074/jbc.m414645200
- tissue_or_cell_type
- Purified enzyme
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 528–539
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified rat enzyme and separate HeLa-cell assays · source_derived_draft · unverified_draft
### curcumin-trx-oxidase The modified enzyme acquired increased NADPH oxidase activity associated with reactive oxygen species production. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The modified protein could consume reducing power while promoting oxidation. organism: Rattus norvegicus tissue_or_cell_type: Purified enzyme experimental_model: Purified rat enzyme and separate HeLa-cell assays limitations: Rat residue numbering Cys496/Sec497 is source-specific and must not replace numbering in other TrxR constructs. Cellular enzyme activity does not prove clinical cancer benefit. exposure: Rat enzyme: two-hour incubation, IC50 3.6 micromolar; HeLa activity IC50 about 15 micromolar evidence_span: {"source_cache": "artifacts/curcumin-research/15879598.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c", "start_char": 0, "end_char": 1659, "text_sha256": "be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c"} [curcumin-p15879598] Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. (2005). https://pubmed.ncbi.nlm.nih.gov/15879598/ DOI: 10.1074/jbc.m414645200
Complete structured claim and evidence
What acts on it
Mass spectrometry and blotting supported modification of Cys496 and Sec497 in the rat enzyme.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/curcumin-research/15879598.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c", "start_char": 0, "end_char": 1659, "text_sha256": "be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c"}
- experimental_model
- Purified rat enzyme and separate HeLa-cell assays
- exposure
- Rat enzyme: two-hour incubation, IC50 3.6 micromolar; HeLa activity IC50 about 15 micromolar
- limitations
- Rat residue numbering Cys496/Sec497 is source-specific and must not replace numbering in other TrxR constructs. Cellular enzyme activity does not prove clinical cancer benefit.
- nutrient_topic
- Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
- organism
- Rattus norvegicus
- plain_language
- The interaction included the selenium-containing active-site residue.
- primary_references
- [curcumin-p15879598] Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. (2005). https://pubmed.ncbi.nlm.nih.gov/15879598/ DOI: 10.1074/jbc.m414645200
- tissue_or_cell_type
- Purified enzyme
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 515–526
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified rat enzyme and separate HeLa-cell assays · source_derived_draft · unverified_draft
### curcumin-trx-adduct Mass spectrometry and blotting supported modification of Cys496 and Sec497 in the rat enzyme. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The interaction included the selenium-containing active-site residue. organism: Rattus norvegicus tissue_or_cell_type: Purified enzyme experimental_model: Purified rat enzyme and separate HeLa-cell assays limitations: Rat residue numbering Cys496/Sec497 is source-specific and must not replace numbering in other TrxR constructs. Cellular enzyme activity does not prove clinical cancer benefit. exposure: Rat enzyme: two-hour incubation, IC50 3.6 micromolar; HeLa activity IC50 about 15 micromolar evidence_span: {"source_cache": "artifacts/curcumin-research/15879598.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c", "start_char": 0, "end_char": 1659, "text_sha256": "be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c"} [curcumin-p15879598] Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. (2005). https://pubmed.ncbi.nlm.nih.gov/15879598/ DOI: 10.1074/jbc.m414645200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.