Component
Rat thyroid glutathione peroxidase activity
Rat thyroid glutathione peroxidase activity
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Thyroid glutathione peroxidase activity in selenium-restricted rats was approximately 40% of that in supplemented groups although thyroid type I deiodinase was maintained.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Selenium supply changes processing/defense associated with iodine-containing thyroid hormones; effects differ by tissue and enzyme.
- evidence_locator
- Primary abstract
- evidence_spans
- [{"source_document": "artifacts/iodine-metabolism-sources/8505673.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1565}]
- experimental_model
- Male weanling Sprague-Dawley rats fed torula-yeast diets for 20 weeks
- exposure
- 20 weeks; basal 0.01 mg Se/kg diet versus basal diet plus sodium selenite reported at 0.05, 0.1 or 0.5 mg Se/kg diet.
- limitations
- Rat feeding study; no universal serum selenium threshold or human repletion dose. Glutathione peroxidase assay does not identify a specific isoform.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Rattus norvegicus
- plain_language
- Selenium restriction affected thyroid antioxidant activity differently from thyroid deiodination.
- primary_references
- [i-met-8505673] Selenium requirements of rats for normal hepatic and thyroidal 5'-deiodinase (type I) activities. (1993). https://pubmed.ncbi.nlm.nih.gov/8505673/ DOI: 10.1093/jn/123.6.1124
- tissue_or_cell_type
- Thyroid
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1084–1097
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Male weanling Sprague-Dawley rats fed torula-yeast diets for 20 weeks · source_derived_draft · unverified_draft
### i-met-se-thyroid-gpx Thyroid glutathione peroxidase activity in selenium-restricted rats was approximately 40% of that in supplemented groups although thyroid type I deiodinase was maintained. Condition category: nutrient_deficiency nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Selenium restriction affected thyroid antioxidant activity differently from thyroid deiodination. organism: Rattus norvegicus tissue_or_cell_type: Thyroid experimental_model: Male weanling Sprague-Dawley rats fed torula-yeast diets for 20 weeks limitations: Rat feeding study; no universal serum selenium threshold or human repletion dose. Glutathione peroxidase assay does not identify a specific isoform. exposure: 20 weeks; basal 0.01 mg Se/kg diet versus basal diet plus sodium selenite reported at 0.05, 0.1 or 0.5 mg Se/kg diet. cross_nutrient: Selenium supply changes processing/defense associated with iodine-containing thyroid hormones; effects differ by tissue and enzyme. evidence_locator: Primary abstract evidence_spans: [{"source_document": "artifacts/iodine-metabolism-sources/8505673.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1565}] [i-met-8505673] Selenium requirements of rats for normal hepatic and thyroidal 5'-deiodinase (type I) activities. (1993). https://pubmed.ncbi.nlm.nih.gov/8505673/ DOI: 10.1093/jn/123.6.1124
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.