{"id":"6b5eb88a-6471-56c6-bdc2-5af441d67565","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:i-met-se-thyroid-gpx","predicate":"modulates","statement":"Thyroid glutathione peroxidase activity in selenium-restricted rats was approximately 40% of that in supplemented groups although thyroid type I deiodinase was maintained.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9189c3c5-7b60-5a02-a1e2-48aa572fdaa6","mechanism_event_label":"Selenium restriction affected thyroid antioxidant activity differently from thyroid deiodination.","subject":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"object":{"id":"cde70c8f-961e-5fc0-9c5a-1e3824618a8a","slug":"rat-thyroid-glutathione-peroxidase-activity","display_name":"Rat thyroid glutathione peroxidase activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9189c3c5-7b60-5a02-a1e2-48aa572fdaa6","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:i-met-se-thyroid-gpx-event","event_type":"biochemical_relationship","label":"Selenium restriction affected thyroid antioxidant activity differently from thyroid deiodination.","description":"Thyroid glutathione peroxidase activity in selenium-restricted rats was approximately 40% of that in supplemented groups although thyroid type I deiodinase was maintained.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"restricted_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"de2bd0a4-622a-5cb2-b31b-f265d621161d","slug":"rat-dio1","display_name":"Rat type 1 iodothyronine deiodinase","entity_type_key":"protein"},"role":"hormone_processing_enzyme","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"hormone_context","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"cde70c8f-961e-5fc0-9c5a-1e3824618a8a","slug":"rat-thyroid-glutathione-peroxidase-activity","display_name":"Rat thyroid glutathione peroxidase activity","entity_type_key":"cellular_process"},"role":"measured_antioxidant_activity","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Selenium supply changes processing/defense associated with iodine-containing thyroid hormones; effects differ by tissue and enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_locator","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_spans","value_text":"[{\"source_document\": \"artifacts/iodine-metabolism-sources/8505673.json\", \"source_field\": \"resultList.result[0].abstractText\", \"start_char\": 0, \"end_char\": 1565}]","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Male weanling Sprague-Dawley rats fed torula-yeast diets for 20 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"20 weeks; basal 0.01 mg Se/kg diet versus basal diet plus sodium selenite reported at 0.05, 0.1 or 0.5 mg Se/kg diet.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rat feeding study; no universal serum selenium threshold or human repletion dose. Glutathione peroxidase assay does not identify a specific isoform.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Selenium restriction affected thyroid antioxidant activity differently from thyroid deiodination.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[i-met-8505673] Selenium requirements of rats for normal hepatic and thyroidal 5'-deiodinase (type I) activities. (1993). https://pubmed.ncbi.nlm.nih.gov/8505673/ DOI: 10.1093/jn/123.6.1124","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thyroid","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"181c2ff6-06c4-51c1-95b7-8575c8729e12","evidence_kind":"source_excerpt","locator":"Lines 1084-1097","start_line":1084,"end_line":1097,"excerpt":"### i-met-se-thyroid-gpx\nThyroid glutathione peroxidase activity in selenium-restricted rats was approximately 40% of that in supplemented groups although thyroid type I deiodinase was maintained.\nCondition category: nutrient_deficiency\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Selenium restriction affected thyroid antioxidant activity differently from thyroid deiodination.\norganism: Rattus norvegicus\ntissue_or_cell_type: Thyroid\nexperimental_model: Male weanling Sprague-Dawley rats fed torula-yeast diets for 20 weeks\nlimitations: Rat feeding study; no universal serum selenium threshold or human repletion dose. Glutathione peroxidase assay does not identify a specific isoform.\nexposure: 20 weeks; basal 0.01 mg Se/kg diet versus basal diet plus sodium selenite reported at 0.05, 0.1 or 0.5 mg Se/kg diet.\ncross_nutrient: Selenium supply changes processing/defense associated with iodine-containing thyroid hormones; effects differ by tissue and enzyme.\nevidence_locator: Primary abstract\nevidence_spans: [{\"source_document\": \"artifacts/iodine-metabolism-sources/8505673.json\", \"source_field\": \"resultList.result[0].abstractText\", \"start_char\": 0, \"end_char\": 1565}]\n[i-met-8505673] Selenium requirements of rats for normal hepatic and thyroidal 5'-deiodinase (type I) activities. (1993). https://pubmed.ncbi.nlm.nih.gov/8505673/ DOI: 10.1093/jn/123.6.1124","model_system":"Male weanling Sprague-Dawley rats fed torula-yeast diets for 20 weeks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [i-met-8505673] Selenium requirements of rats for normal hepatic and thyroidal 5'-deiodinase (type I) activities. (1993). https://pubmed.ncbi.nlm.nih.gov/8505673/ DOI: 10.1093/jn/123.6.1124","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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