Component

Rat Slc2a13 (HMIT)

Rat Slc2a13 (HMIT). Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. HMIT expressed in Xenopus oocytes mediated electrogenic proton-coupled myo-inositol uptake that increased as pH fell, with maximal tested activity near pH 5.

    Rat Slc2a13 (HMIT) → Myo-inositol source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/11500374.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fb9efd53bbc0fae1bf1ada1525cdb7d10a4e700d3309bfba4e3a598c4a9c74b9", "start_char": 0, "end_char": 1270, "text_sha256": "fb9efd53bbc0fae1bf1ada1525cdb7d10a4e700d3309bfba4e3a598c4a9c74b9"}
    experimental_model
    Transporter expression and electrophysiology
    exposure
    Extracellular pH manipulation
    limitations
    Transport capacity after heterologous expression does not establish a neuronal plasma-membrane role in vivo.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Rat brain transporter studied in Xenopus oocytes
    plain_language
    A different transporter can use a proton gradient, particularly in acidic experimental conditions.
    primary_references
    [ino-p11500374] Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. (2001). https://pubmed.ncbi.nlm.nih.gov/11500374/ DOI: 10.1093/emboj/20.16.4467
    tissue_or_cell_type
    Heterologous membranes and rat brain
    transport_effect
    raises Electrogenic proton-coupled myo-inositol uptake rising as pH fell.
    transport_pool
    the expressing cell Electrogenic proton-coupled myo-inositol uptake rising as pH fell.

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 366–377

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter expression and electrophysiology · source_derived_draft · unverified_draft

    ### ino-hmit-acid HMIT expressed in Xenopus oocytes mediated electrogenic proton-coupled myo-inositol uptake that increased as pH fell, with maximal tested activity near pH 5. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: A different transporter can use a proton gradient, particularly in acidic experimental conditions. organism: Rat brain transporter studied in Xenopus oocytes tissue_or_cell_type: Heterologous membranes and rat brain experimental_model: Transporter expression and electrophysiology limitations: Transport capacity after heterologous expression does not establish a neuronal plasma-membrane role in vivo. exposure: Extracellular pH manipulation evidence_span: {"source_cache": "artifacts/inositol-research/11500374.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fb9efd53bbc0fae1bf1ada1525cdb7d10a4e700d3309bfba4e3a598c4a9c74b9", "start_char": 0, "end_char": 1270, "text_sha256": "fb9efd53bbc0fae1bf1ada1525cdb7d10a4e700d3309bfba4e3a598c4a9c74b9"} [ino-p11500374] Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. (2001). https://pubmed.ncbi.nlm.nih.gov/11500374/ DOI: 10.1093/emboj/20.16.4467
    Complete structured claim and evidence

  2. HMIT localized to the Golgi apparatus in primary cultured neurons; HMIT-mediated currents were not detected in rat neurons or brain slices.

    Rat Slc2a13 (HMIT) → Golgi apparatus source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/19607714.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8b8bd010f44dd8b055efc345c57791e88547114b0a2f27d782183674fc53f984", "start_char": 0, "end_char": 1332, "text_sha256": "8b8bd010f44dd8b055efc345c57791e88547114b0a2f27d782183674fc53f984"}
    experimental_model
    Immunolocalization, neuronal electrophysiology and knockout
    exposure
    Native localization and HMIT-null comparisons
    limitations
    Native localization qualifies earlier heterologous uptake findings; it is an explained context difference, not evidence that one experiment is false.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Rat and human brain; mouse knockout
    plain_language
    A transporter that works at an artificial cell surface may normally function inside the cell.
    primary_references
    [ino-p19607714] Evaluation of expression and function of the H+/myo-inositol transporter HMIT. (2009). https://pubmed.ncbi.nlm.nih.gov/19607714/ DOI: 10.1186/1471-2121-10-54
    tissue_or_cell_type
    Brain neurons and cultured neurons

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 379–390

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Immunolocalization, neuronal electrophysiology and knockout · source_derived_draft · unverified_draft

    ### ino-hmit-golgi HMIT localized to the Golgi apparatus in primary cultured neurons; HMIT-mediated currents were not detected in rat neurons or brain slices. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transporter that works at an artificial cell surface may normally function inside the cell. organism: Rat and human brain; mouse knockout tissue_or_cell_type: Brain neurons and cultured neurons experimental_model: Immunolocalization, neuronal electrophysiology and knockout limitations: Native localization qualifies earlier heterologous uptake findings; it is an explained context difference, not evidence that one experiment is false. exposure: Native localization and HMIT-null comparisons evidence_span: {"source_cache": "artifacts/inositol-research/19607714.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8b8bd010f44dd8b055efc345c57791e88547114b0a2f27d782183674fc53f984", "start_char": 0, "end_char": 1332, "text_sha256": "8b8bd010f44dd8b055efc345c57791e88547114b0a2f27d782183674fc53f984"} [ino-p19607714] Evaluation of expression and function of the H+/myo-inositol transporter HMIT. (2009). https://pubmed.ncbi.nlm.nih.gov/19607714/ DOI: 10.1186/1471-2121-10-54
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards