{"id":"aa109f51-904d-52b6-9864-1c852b2029c7","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-hmit-golgi","predicate":"localizes_to","statement":"HMIT localized to the Golgi apparatus in primary cultured neurons; HMIT-mediated currents were not detected in rat neurons or brain slices.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"86e60bd0-b3c7-5ac1-a153-a29254da293a","mechanism_event_label":"A transporter that works at an artificial cell surface may normally function inside the cell.","subject":{"id":"7066f121-8bfe-5e37-a249-382b116ec5ec","slug":"rat-slc2a13","display_name":"Rat Slc2a13 (HMIT)","entity_type_key":"protein"},"object":{"id":"4a1f62be-aa56-54b0-9417-196b700fa165","slug":"golgi-apparatus","display_name":"Golgi apparatus","entity_type_key":"organelle"},"evidence_count":1,"mechanism_event":{"id":"86e60bd0-b3c7-5ac1-a153-a29254da293a","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-hmit-golgi-event","event_type":"biochemical_relationship","label":"A transporter that works at an artificial cell surface may normally function inside the cell.","description":"HMIT localized to the Golgi apparatus in primary cultured neurons; HMIT-mediated currents were not detected in rat neurons or brain slices.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7066f121-8bfe-5e37-a249-382b116ec5ec","slug":"rat-slc2a13","display_name":"Rat Slc2a13 (HMIT)","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4a1f62be-aa56-54b0-9417-196b700fa165","slug":"golgi-apparatus","display_name":"Golgi apparatus","entity_type_key":"organelle"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/inositol-research/19607714.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8b8bd010f44dd8b055efc345c57791e88547114b0a2f27d782183674fc53f984\", \"start_char\": 0, \"end_char\": 1332, \"text_sha256\": \"8b8bd010f44dd8b055efc345c57791e88547114b0a2f27d782183674fc53f984\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Immunolocalization, neuronal electrophysiology and knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Native localization and HMIT-null comparisons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Native localization qualifies earlier heterologous uptake findings; it is an explained context difference, not evidence that one experiment is false.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rat and human brain; mouse knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A transporter that works at an artificial cell surface may normally function inside the cell.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p19607714] Evaluation of expression and function of the H+/myo-inositol transporter HMIT. 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