Component

Rat divalent metal transporter 1 / Slc11a2

Rat divalent metal transporter 1 / Slc11a2. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The original rat DCT1 expression assay also transported Mn(II), among other divalent metals.

    Rat divalent metal transporter 1 / Slc11a2 → Mn2+ source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/iron-research/9242408.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52", "start_char": 0, "end_char": 1203, "text_sha256": "0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52"}
    experimental_model
    Cloning and functional expression of DCT1/DMT1
    exposure
    Metal-ion uptake, membrane potential and iron-deficient feeding
    limitations
    Original broad substrate profile; later substrate-specific studies and species differences must be retained. Competition in an assay is not a universal dietary interaction.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    Rat transporter
    plain_language
    Iron shares this transporter with other metals, making the transport setting important.
    primary_references
    [iron-p9242408] Cloning and characterization of a mammalian proton-coupled metal-ion transporter. (1997). https://pubmed.ncbi.nlm.nih.gov/9242408/ DOI: 10.1038/41343
    tissue_or_cell_type
    Transport assay and duodenal expression

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 407–418

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cloning and functional expression of DCT1/DMT1 · source_derived_draft · unverified_draft

    ### iron-dmt-other-metals The original rat DCT1 expression assay also transported Mn(II), among other divalent metals. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron shares this transporter with other metals, making the transport setting important. organism: Rat transporter tissue_or_cell_type: Transport assay and duodenal expression experimental_model: Cloning and functional expression of DCT1/DMT1 limitations: Original broad substrate profile; later substrate-specific studies and species differences must be retained. Competition in an assay is not a universal dietary interaction. exposure: Metal-ion uptake, membrane potential and iron-deficient feeding evidence_span: {"source_cache": "artifacts/iron-research/9242408.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52", "start_char": 0, "end_char": 1203, "text_sha256": "0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52"} [iron-p9242408] Cloning and characterization of a mammalian proton-coupled metal-ion transporter. (1997). https://pubmed.ncbi.nlm.nih.gov/9242408/ DOI: 10.1038/41343
    Complete structured claim and evidence

  2. Rat DCT1/DMT1 mediated proton-coupled Fe(II) transport that depended on membrane potential.

    Rat divalent metal transporter 1 / Slc11a2 → Ferrous iron source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/iron-research/9242408.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52", "start_char": 0, "end_char": 1203, "text_sha256": "0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52"}
    experimental_model
    Cloning and functional expression of DCT1/DMT1
    exposure
    Metal-ion uptake, membrane potential and iron-deficient feeding
    limitations
    Original broad substrate profile; later substrate-specific studies and species differences must be retained. Competition in an assay is not a universal dietary interaction.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    Rat transporter
    plain_language
    The uptake protein uses an electrochemical gradient to bring ferrous iron into cells.
    primary_references
    [iron-p9242408] Cloning and characterization of a mammalian proton-coupled metal-ion transporter. (1997). https://pubmed.ncbi.nlm.nih.gov/9242408/ DOI: 10.1038/41343
    tissue_or_cell_type
    Transport assay and duodenal expression
    transport_effect
    raises Proton-coupled and membrane-potential-dependent Fe(II) transport, which is inward.
    transport_pool
    the expressing cell Proton-coupled and membrane-potential-dependent Fe(II) transport, which is inward.

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 394–405

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cloning and functional expression of DCT1/DMT1 · source_derived_draft · unverified_draft

    ### iron-dmt-proton-transport Rat DCT1/DMT1 mediated proton-coupled Fe(II) transport that depended on membrane potential. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The uptake protein uses an electrochemical gradient to bring ferrous iron into cells. organism: Rat transporter tissue_or_cell_type: Transport assay and duodenal expression experimental_model: Cloning and functional expression of DCT1/DMT1 limitations: Original broad substrate profile; later substrate-specific studies and species differences must be retained. Competition in an assay is not a universal dietary interaction. exposure: Metal-ion uptake, membrane potential and iron-deficient feeding evidence_span: {"source_cache": "artifacts/iron-research/9242408.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52", "start_char": 0, "end_char": 1203, "text_sha256": "0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52"} [iron-p9242408] Cloning and characterization of a mammalian proton-coupled metal-ion transporter. (1997). https://pubmed.ncbi.nlm.nih.gov/9242408/ DOI: 10.1038/41343
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards