{"id":"d6fb4439-c5bf-5cda-b263-eb7c8e24aad6","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-dmt-other-metals","predicate":"also_transports","statement":"The original rat DCT1 expression assay also transported Mn(II), among other divalent metals.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8c1ff1ed-e66c-5c96-8987-00b16c666047","mechanism_event_label":"Iron shares this transporter with other metals, making the transport setting important.","subject":{"id":"03f990dd-91bb-52ab-8a8c-740ccf50b3f1","slug":"rat-slc11a2","display_name":"Rat divalent metal transporter 1 / Slc11a2","entity_type_key":"protein"},"object":{"id":"a8082b11-c484-5792-bb81-48e8e699cbe4","slug":"manganese-ion","display_name":"Mn2+","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"8c1ff1ed-e66c-5c96-8987-00b16c666047","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-dmt-other-metals-event","event_type":"biochemical_relationship","label":"Iron shares this transporter with other metals, making the transport setting important.","description":"The original rat DCT1 expression assay also transported Mn(II), among other divalent metals.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"role":"other_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"03f990dd-91bb-52ab-8a8c-740ccf50b3f1","slug":"rat-slc11a2","display_name":"Rat divalent metal transporter 1 / Slc11a2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a8082b11-c484-5792-bb81-48e8e699cbe4","slug":"manganese-ion","display_name":"Mn2+","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/9242408.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52\", \"start_char\": 0, \"end_char\": 1203, \"text_sha256\": \"0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cloning and functional expression of DCT1/DMT1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Metal-ion uptake, membrane potential and iron-deficient feeding","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Original broad substrate profile; later substrate-specific studies and species differences must be retained. Competition in an assay is not a universal dietary interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat transporter","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Iron shares this transporter with other metals, making the transport setting important.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p9242408] Cloning and characterization of a mammalian proton-coupled metal-ion transporter. (1997). https://pubmed.ncbi.nlm.nih.gov/9242408/ DOI: 10.1038/41343","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Transport assay and duodenal expression","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f98bbc96-003c-5186-a545-200cb481ea7e","evidence_kind":"source_excerpt","locator":"Lines 407-418","start_line":407,"end_line":418,"excerpt":"### iron-dmt-other-metals\nThe original rat DCT1 expression assay also transported Mn(II), among other divalent metals.\nCondition category: normal\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Iron shares this transporter with other metals, making the transport setting important.\norganism: Rat transporter\ntissue_or_cell_type: Transport assay and duodenal expression\nexperimental_model: Cloning and functional expression of DCT1/DMT1\nlimitations: Original broad substrate profile; later substrate-specific studies and species differences must be retained. Competition in an assay is not a universal dietary interaction.\nexposure: Metal-ion uptake, membrane potential and iron-deficient feeding\nevidence_span: {\"source_cache\": \"artifacts/iron-research/9242408.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52\", \"start_char\": 0, \"end_char\": 1203, \"text_sha256\": \"0b5241ac49e6de4e273c91f36387357c9bd76ce602e44defffc3b8b42191fe52\"}\n[iron-p9242408] Cloning and characterization of a mammalian proton-coupled metal-ion transporter. (1997). https://pubmed.ncbi.nlm.nih.gov/9242408/ DOI: 10.1038/41343","model_system":"Cloning and functional expression of DCT1/DMT1","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iron-p9242408] Cloning and characterization of a mammalian proton-coupled metal-ion transporter. (1997). https://pubmed.ncbi.nlm.nih.gov/9242408/ DOI: 10.1038/41343","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1560864c-91d1-58dc-90c4-49bf61aba3de","stable_key":"import-e13b03e1-a614-543a-ac1b-97df18cfe30d","title":"Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f9dab767a21c9bbfef3227707fe3c82953536bb1335599dd4ef93b5ea2dbf03f","revision_id":"77700d7f-2902-54b9-adae-8cbc77b24682","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}