Component
NMDA-receptor signaling in the rat SCN
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
NMDA-receptor antagonists blocked glycine-associated cutaneous blood-flow responses in the rat experiments, whereas strychnine did not.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Rat brain injection and antagonist experiments.
- limitations
- Antagonist evidence supports pathway involvement; does not show all sleep effects use this route.
- nutrient_topic
- Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
- plain_language
- The tested sleep-related response used a different receptor route from the inhibitory glycine channel.
- primary_references
- The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25533534/ · DOI 10.1038/npp.2014.326
Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 418–424
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat brain injection and antagonist experiments. · source_derived_draft · unverified_draft
## glycine-sleep-nmda-route The tested sleep-related response used a different receptor route from the inhibitory glycine channel. NMDA-receptor antagonists blocked glycine-associated cutaneous blood-flow responses in the rat experiments, whereas strychnine did not. Model: Rat brain injection and antagonist experiments. Limitations: Antagonist evidence supports pathway involvement; does not show all sleep effects use this route. Evidence access: Primary abstract The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25533534/ · DOI 10.1038/npp.2014.326
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.