{"id":"22672ec8-5213-55da-98b6-83e8a0e6082c","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-sleep-nmda-route","predicate":"mediates_tested","statement":"NMDA-receptor antagonists blocked glycine-associated cutaneous blood-flow responses in the rat experiments, whereas strychnine did not.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bcdc9eb4-0f99-5d85-aab8-5c220eaa4411","mechanism_event_label":"The tested sleep-related response used a different receptor route from the inhibitory glycine channel.","subject":{"id":"4dc925ce-129f-5373-b709-801d6bf0ce76","slug":"rat-scn-nmda-receptor-signaling","display_name":"NMDA-receptor signaling in the rat SCN","entity_type_key":"cellular_process"},"object":{"id":"b6380207-6615-519a-96a3-4dcc8e4155d6","slug":"rat-scn-glycine-heat-loss","display_name":"SCN-dependent heat loss and sleep response in rats","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bcdc9eb4-0f99-5d85-aab8-5c220eaa4411","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-sleep-nmda-route-event","event_type":"observed_relationship","label":"The tested sleep-related response used a different receptor route from the inhibitory glycine channel.","description":"NMDA-receptor antagonists blocked glycine-associated cutaneous blood-flow responses in the rat experiments, whereas strychnine did not.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4dc925ce-129f-5373-b709-801d6bf0ce76","slug":"rat-scn-nmda-receptor-signaling","display_name":"NMDA-receptor signaling in the rat SCN","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6380207-6615-519a-96a3-4dcc8e4155d6","slug":"rat-scn-glycine-heat-loss","display_name":"SCN-dependent heat loss and sleep response in rats","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat brain injection and antagonist experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Antagonist evidence supports pathway involvement; does not show all sleep effects use this route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The tested sleep-related response used a different receptor route from the inhibitory glycine channel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25533534/ · DOI 10.1038/npp.2014.326","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"425c85cd-ebd1-559a-a838-50d39f672434","evidence_kind":"source_excerpt","locator":"Lines 418-424","start_line":418,"end_line":424,"excerpt":"## glycine-sleep-nmda-route\nThe tested sleep-related response used a different receptor route from the inhibitory glycine channel.\nNMDA-receptor antagonists blocked glycine-associated cutaneous blood-flow responses in the rat experiments, whereas strychnine did not.\nModel: Rat brain injection and antagonist experiments.\nLimitations: Antagonist evidence supports pathway involvement; does not show all sleep effects use this route.\nEvidence access: Primary abstract\nThe sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25533534/ · DOI 10.1038/npp.2014.326","model_system":"Rat brain injection and antagonist experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"4fabd2fc8e71ca156c91023e7340be3f5a02ae03e91d3a24b231c2adfb0de0aa","revision_id":"24801e49-34a8-53c3-bdf5-b59143441450","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}