Component
Rat renal p47phox/gp91phox abundance during SAC/cisplatin exposure
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SAC attenuated cisplatin-associated increases in renal p47phox and gp91phox expression.
Experimental context and source evidence
- acting_entity
- s-allylcysteine
- dose
- SAC 25 mg/kg; cisplatin dose not retrieved
- duration
- Single SAC dose for signaling arm; timing not retrieved
- evidence_access
- Primary abstract
- experimental_comparison
- SAC with cisplatin versus cisplatin injury controls
- experimental_model
- Cisplatin-challenged renal cortex and isolated proximal/distal tubules
- interpretation_status
- Source-derived research curation; not independent primary verification
- limitations
- Expression endpoints do not establish direct inhibition of the assembled NADPH oxidase.
- nutrient_topic
- S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · S-allyl-L-cysteine / SAC
- organism
- Rattus norvegicus
- plain_language
- Components of a ROS-producing system changed.
- primary_references
- [24779924] S-allylcysteine prevents cisplatin-induced nephrotoxicity and oxidative stress. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24779924/ · DOI 10.1111/jphp.12263
- route
- Administration route not specified in accessed abstract
- tissue_or_cell_type
- Cisplatin-challenged renal cortex and isolated proximal/distal tubules
S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20) · lines 347–354
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Cisplatin-challenged renal cortex and isolated proximal/distal tubules · source_derived_draft · unverified_draft
## s-allylcysteine-cisplatin-nox Components of a ROS-producing system changed. SAC attenuated cisplatin-associated increases in renal p47phox and gp91phox expression. Model: Cisplatin-challenged renal cortex and isolated proximal/distal tubules Limitations: Expression endpoints do not establish direct inhibition of the assembled NADPH oxidase. Evidence access: Primary abstract [24779924] S-allylcysteine prevents cisplatin-induced nephrotoxicity and oxidative stress. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24779924/ · DOI 10.1111/jphp.12263 Structured context: {"organism": "Rattus norvegicus", "tissue_or_cell_type": "Cisplatin-challenged renal cortex and isolated proximal/distal tubules", "dose": "SAC 25 mg/kg; cisplatin dose not retrieved", "duration": "Single SAC dose for signaling arm; timing not retrieved", "route": "Administration route not specified in accessed abstract", "experimental_comparison": "SAC with cisplatin versus cisplatin injury controls", "acting_entity": "s-allylcysteine", "interpretation_status": "Source-derived research curation; not independent primary verification"}
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.