{"id":"af388c70-37fc-5b4c-84ab-2e2ae1761c7c","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-cisplatin-nox","predicate":"reduces_tested","statement":"SAC attenuated cisplatin-associated increases in renal p47phox and gp91phox expression.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"869fa427-9cf5-536a-9652-d326245f4dd4","mechanism_event_label":"Components of a ROS-producing system changed.","subject":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"object":{"id":"a6843410-471c-53c0-b537-5a45f40a9aed","slug":"rat-sac-renal-nox-subunits","display_name":"Rat renal p47phox/gp91phox abundance during SAC/cisplatin exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"869fa427-9cf5-536a-9652-d326245f4dd4","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-cisplatin-nox-event","event_type":"observed_relationship","label":"Components of a ROS-producing system changed.","description":"SAC attenuated cisplatin-associated increases in renal p47phox and gp91phox expression.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a6843410-471c-53c0-b537-5a45f40a9aed","slug":"rat-sac-renal-nox-subunits","display_name":"Rat renal p47phox/gp91phox abundance during SAC/cisplatin exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bdb83796-78cf-5b54-9ca6-4dab19b33600","slug":"cisplatin","display_name":"Cisplatin","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"s-allylcysteine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"SAC 25 mg/kg; cisplatin dose not retrieved","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Single SAC dose for signaling arm; timing not retrieved","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_comparison","value_text":"SAC with cisplatin versus cisplatin injury controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cisplatin-challenged renal cortex and isolated proximal/distal tubules","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived research curation; not independent primary verification","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression endpoints do not establish direct inhibition of the assembled NADPH oxidase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Components of a ROS-producing system changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[24779924] S-allylcysteine prevents cisplatin-induced nephrotoxicity and oxidative stress. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24779924/ · DOI 10.1111/jphp.12263","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Administration route not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cisplatin-challenged renal cortex and isolated proximal/distal tubules","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"80e0468b-da60-55ad-8eee-4713d1d0facc","evidence_kind":"source_excerpt","locator":"Lines 347-354","start_line":347,"end_line":354,"excerpt":"## s-allylcysteine-cisplatin-nox\nComponents of a ROS-producing system changed.\nSAC attenuated cisplatin-associated increases in renal p47phox and gp91phox expression.\nModel: Cisplatin-challenged renal cortex and isolated proximal/distal tubules\nLimitations: Expression endpoints do not establish direct inhibition of the assembled NADPH oxidase.\nEvidence access: Primary abstract\n[24779924] S-allylcysteine prevents cisplatin-induced nephrotoxicity and oxidative stress. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24779924/ · DOI 10.1111/jphp.12263\nStructured context: {\"organism\": \"Rattus norvegicus\", \"tissue_or_cell_type\": \"Cisplatin-challenged renal cortex and isolated proximal/distal tubules\", \"dose\": \"SAC 25 mg/kg; cisplatin dose not retrieved\", \"duration\": \"Single SAC dose for signaling arm; timing not retrieved\", \"route\": \"Administration route not specified in accessed abstract\", \"experimental_comparison\": \"SAC with cisplatin versus cisplatin injury controls\", \"acting_entity\": \"s-allylcysteine\", \"interpretation_status\": \"Source-derived research curation; not independent primary verification\"}","model_system":"Cisplatin-challenged renal cortex and isolated proximal/distal tubules","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3b0d58f9-8a69-579d-9920-518399a9a8bb","stable_key":"import-d96b230c-481b-535b-930c-04eb87ec7f02","title":"S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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