Component
IGF-I expression in rat Dunning prostate tumors
IGF-I expression in rat Dunning prostate tumors. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lycopene downregulated local IGF-I expression in the rat tumor experiment.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/15084515.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "682a0c4c6a001993efa3bada4aa3d381723feb78b410fd703b8de72517eef62c", "start_char": 0, "end_char": 1410, "text_sha256": "682a0c4c6a001993efa3bada4aa3d381723feb78b410fd703b8de72517eef62c"}
- experimental_model
- Dietary intervention and tumor gene-expression analysis
- exposure
- 200 ppm lycopene, 540 ppm vitamin E or both for four weeks
- limitations
- Preclinical gene-expression findings; not established human steroid suppression or cancer treatment.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Rat MatLyLu Dunning prostate tumor model
- plain_language
- This was local tumor signaling, not measured human blood IGF-I.
- primary_references
- [lycopene-p15084515] Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. (2004). https://pubmed.ncbi.nlm.nih.gov/15084515/ DOI: 10.1096/fj.03-1116fje
- tissue_or_cell_type
- Tumor tissue
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 910–921
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary intervention and tumor gene-expression analysis · source_derived_draft · unverified_draft
### lycopene-rat-igf Lycopene downregulated local IGF-I expression in the rat tumor experiment. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was local tumor signaling, not measured human blood IGF-I. organism: Rat MatLyLu Dunning prostate tumor model tissue_or_cell_type: Tumor tissue experimental_model: Dietary intervention and tumor gene-expression analysis limitations: Preclinical gene-expression findings; not established human steroid suppression or cancer treatment. exposure: 200 ppm lycopene, 540 ppm vitamin E or both for four weeks evidence_span: {"source_cache": "artifacts/lycopene-research/15084515.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "682a0c4c6a001993efa3bada4aa3d381723feb78b410fd703b8de72517eef62c", "start_char": 0, "end_char": 1410, "text_sha256": "682a0c4c6a001993efa3bada4aa3d381723feb78b410fd703b8de72517eef62c"} [lycopene-p15084515] Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. (2004). https://pubmed.ncbi.nlm.nih.gov/15084515/ DOI: 10.1096/fj.03-1116fje
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.