Component
Rat phosphatidylinositol 3-kinase complexes (isoform unresolved)
Rat phosphatidylinositol 3-kinase complexes (isoform unresolved). Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Chromium picolinate increased insulin-stimulated PI3K activity in muscle from the obese rats without increasing PI3K protein abundance.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chromium-research/16424121.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b0fa1d0917ec9cf4f3d309f2e9eb0e2b498e083ed1ff881b8f8df94a3cbe8119", "start_char": 0, "end_char": 1734, "text_sha256": "b0fa1d0917ec9cf4f3d309f2e9eb0e2b498e083ed1ff881b8f8df94a3cbe8119"}
- experimental_model
- Three-month supplementation and acute muscle insulin-signaling experiment
- exposure
- Chromium picolinate supplying approximately 80 µg Cr/kg/day; small obese and lean treatment groups
- limitations
- Model-specific supplementation. Lower phosphatase protein and activity do not prove direct chromium binding to PTP1B. Different results from cultured adipocytes are contextual, not a reason to erase either study.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Male JCR:LA-cp obese and lean rats
- plain_language
- Another downstream insulin-signaling step became more active.
- primary_references
- [chromium-p16424121] Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats. (2006). https://pubmed.ncbi.nlm.nih.gov/16424121/ DOI: 10.1093/jn/136.2.415
- tissue_or_cell_type
- Vastus lateralis skeletal muscle
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 432–443
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three-month supplementation and acute muscle insulin-signaling experiment · source_derived_draft · unverified_draft
### chromium-rat-pi3k-activity Chromium picolinate increased insulin-stimulated PI3K activity in muscle from the obese rats without increasing PI3K protein abundance. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Another downstream insulin-signaling step became more active. organism: Male JCR:LA-cp obese and lean rats tissue_or_cell_type: Vastus lateralis skeletal muscle experimental_model: Three-month supplementation and acute muscle insulin-signaling experiment limitations: Model-specific supplementation. Lower phosphatase protein and activity do not prove direct chromium binding to PTP1B. Different results from cultured adipocytes are contextual, not a reason to erase either study. exposure: Chromium picolinate supplying approximately 80 µg Cr/kg/day; small obese and lean treatment groups evidence_span: {"source_cache": "artifacts/chromium-research/16424121.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b0fa1d0917ec9cf4f3d309f2e9eb0e2b498e083ed1ff881b8f8df94a3cbe8119", "start_char": 0, "end_char": 1734, "text_sha256": "b0fa1d0917ec9cf4f3d309f2e9eb0e2b498e083ed1ff881b8f8df94a3cbe8119"} [chromium-p16424121] Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats. (2006). https://pubmed.ncbi.nlm.nih.gov/16424121/ DOI: 10.1093/jn/136.2.415
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.