Component
Rat phlorizin phase-I and phase-II metabolite pool
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
High-dose rat studies identified hydroxylated, reduced, methylated, acetylated, sulfated and glucuronidated phlorizin metabolites in plasma, urine or feces.
Experimental context and source evidence
- dose
- Phlorizin; reported pharmacokinetic arm included 400 mg/kg intraperitoneally
- duration
- 1-6 hour parent/aglycone peaks and excretion sampling
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Sprague-Dawley rats
- limitations
- The dose is very high; proposed stronger metabolite inhibition of SGLTs came from docking, not functional transport experiments.
- nutrient_topic
- Phlorizin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Phlorizin
- organism
- Sprague-Dawley rats
- plain_language
- High-dose rat studies identified hydroxylated, reduced, methylated, acetylated, sulfated and glucuronidated phlorizin metabolites in plasma, urine or feces.
- primary_references
- A pharmacokinetic study to correlate the hypoglycemic effect of phlorizin in rats: Identification of metabolites as inhibitors of sodium/glucose cotransporters. (2023). https://pubmed.ncbi.nlm.nih.gov/37464563/ DOI: 10.1002/jms.4964
- route
- Intraperitoneal and sampled excreta; oral samples also described
- tissue
- LC-MS/MS pharmacokinetics and metabolite identification
Phlorizin: mechanism of action and interactions (2026-09-20) · lines 88–97
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Sprague-Dawley rats · source_derived_draft · unverified_draft
## phlorizin-rat-metabolites High-dose rat studies identified hydroxylated, reduced, methylated, acetylated, sulfated and glucuronidated phlorizin metabolites in plasma, urine or feces. Model/species: Sprague-Dawley rats Tissue/system: LC-MS/MS pharmacokinetics and metabolite identification Exposure: Phlorizin; reported pharmacokinetic arm included 400 mg/kg intraperitoneally Route: Intraperitoneal and sampled excreta; oral samples also described Duration: 1-6 hour parent/aglycone peaks and excretion sampling Limits: The dose is very high; proposed stronger metabolite inhibition of SGLTs came from docking, not functional transport experiments. Primary reference: A pharmacokinetic study to correlate the hypoglycemic effect of phlorizin in rats: Identification of metabolites as inhibitors of sodium/glucose cotransporters. (2023). https://pubmed.ncbi.nlm.nih.gov/37464563/ DOI: 10.1002/jms.4964 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.