Component
Rat NAD-dependent pyridoxal dehydrogenase activity
Partially purified tissue activity; molecular isoenzyme identity not assigned.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Partially purified rat tissue NAD-dependent aldehyde-dehydrogenase activity oxidized PL to 4-pyridoxic acid; oxidase-null rats still excreted the acid.
Experimental context and source evidence
- cross_nutrient
- NAD links niacin-derived redox chemistry to B6 catabolism in this rat assay.
- evidence_location
- Indexed abstract: partially purified rat enzyme and urinary metabolites
- experimental_model
- Rat tissue enzyme fractions and aldehyde-oxidase activity variants.
- exposure
- Partially purified activity; kinetic assays at pH 9.6.
- limitations
- Molecular isoenzyme and quantitative contribution in humans not established.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Rattus norvegicus
- plain_language
- Rat B6 breakdown had an alternative to aldehyde oxidase.
- primary_references
- [stanulovic1976] New pathway of conversion of pyridoxal to 4-pyridoxic acid. (1976). https://pubmed.ncbi.nlm.nih.gov/939227/ DOI: 10.1159/000458879
- tissue_or_cell_type
- Rat tissue enzyme fractions and urine
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 491–503
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat tissue enzyme fractions and aldehyde-oxidase activity variants. · source_derived_draft · unverified_draft
### b6-transport-rat-pl-catabolism Partially purified rat tissue NAD-dependent aldehyde-dehydrogenase activity oxidized PL to 4-pyridoxic acid; oxidase-null rats still excreted the acid. Condition category: normal nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Rat B6 breakdown had an alternative to aldehyde oxidase. organism: Rattus norvegicus tissue_or_cell_type: Rat tissue enzyme fractions and urine experimental_model: Rat tissue enzyme fractions and aldehyde-oxidase activity variants. limitations: Molecular isoenzyme and quantitative contribution in humans not established. exposure: Partially purified activity; kinetic assays at pH 9.6. evidence_location: Indexed abstract: partially purified rat enzyme and urinary metabolites cross_nutrient: NAD links niacin-derived redox chemistry to B6 catabolism in this rat assay. [stanulovic1976] New pathway of conversion of pyridoxal to 4-pyridoxic acid. (1976). https://pubmed.ncbi.nlm.nih.gov/939227/ DOI: 10.1159/000458879
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.