Component

Rat hepatic glutamate-cysteine ligase activity

Rat hepatic glutamate-cysteine ligase activity. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Older rat liver showed lower GCLC/GCLM expression and about 53% lower GCL activity than young liver.

    Rat glutamate-cysteine ligase catalytic subunit / Gclc → Rat hepatic glutamate-cysteine ligase activity source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/ala-research/14985508.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13", "start_char": 0, "end_char": 1696, "text_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13"}
    experimental_model
    Aging-rat liver biochemistry and R-lipoic-acid intervention
    exposure
    R-lipoic acid 40 mg/kg intraperitoneally; time course up to 48 hours
    limitations
    Animal injection study; changes in enzyme expression are distinct from direct radical scavenging and human clinical efficacy.
    nutrient_topic
    Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
    organism
    Rat
    plain_language
    Aging changed the machinery that makes glutathione in this model.
    primary_references
    [ala-p14985508] Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. (2004). https://pubmed.ncbi.nlm.nih.gov/14985508/ DOI: 10.1073/pnas.0400282101
    tissue_or_cell_type
    Liver
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 832–843

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Aging-rat liver biochemistry and R-lipoic-acid intervention · source_derived_draft · unverified_draft

    ### ala-aging-gcl-capacity Older rat liver showed lower GCLC/GCLM expression and about 53% lower GCL activity than young liver. Condition category: machinery_impairment nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Aging changed the machinery that makes glutathione in this model. organism: Rat tissue_or_cell_type: Liver experimental_model: Aging-rat liver biochemistry and R-lipoic-acid intervention limitations: Animal injection study; changes in enzyme expression are distinct from direct radical scavenging and human clinical efficacy. exposure: R-lipoic acid 40 mg/kg intraperitoneally; time course up to 48 hours evidence_span: {"source_cache": "artifacts/ala-research/14985508.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13", "start_char": 0, "end_char": 1696, "text_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13"} [ala-p14985508] Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. (2004). https://pubmed.ncbi.nlm.nih.gov/14985508/ DOI: 10.1073/pnas.0400282101
    Complete structured claim and evidence

  2. R-lipoic-acid treatment increased GCLC and GCL activity at the later measured time point in aged rat liver.

    Free R-alpha-lipoic acid → Rat hepatic glutamate-cysteine ligase activity source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ala-research/14985508.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13", "start_char": 0, "end_char": 1696, "text_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13"}
    experimental_model
    Aging-rat liver biochemistry and R-lipoic-acid intervention
    exposure
    R-lipoic acid 40 mg/kg intraperitoneally; time course up to 48 hours
    limitations
    Animal injection study; changes in enzyme expression are distinct from direct radical scavenging and human clinical efficacy.
    nutrient_topic
    Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
    organism
    Rat
    plain_language
    The liver increased part of its glutathione-making capacity.
    primary_references
    [ala-p14985508] Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. (2004). https://pubmed.ncbi.nlm.nih.gov/14985508/ DOI: 10.1073/pnas.0400282101
    tissue_or_cell_type
    Liver

    Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 858–869

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Aging-rat liver biochemistry and R-lipoic-acid intervention · source_derived_draft · unverified_draft

    ### ala-rla-gcl-rat R-lipoic-acid treatment increased GCLC and GCL activity at the later measured time point in aged rat liver. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The liver increased part of its glutathione-making capacity. organism: Rat tissue_or_cell_type: Liver experimental_model: Aging-rat liver biochemistry and R-lipoic-acid intervention limitations: Animal injection study; changes in enzyme expression are distinct from direct radical scavenging and human clinical efficacy. exposure: R-lipoic acid 40 mg/kg intraperitoneally; time course up to 48 hours evidence_span: {"source_cache": "artifacts/ala-research/14985508.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13", "start_char": 0, "end_char": 1696, "text_sha256": "a43d83e66af102cc530c2cb2da20c79749ab5c85c815e573e9797f9fc6645d13"} [ala-p14985508] Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. (2004). https://pubmed.ncbi.nlm.nih.gov/14985508/ DOI: 10.1073/pnas.0400282101
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards