Component
Rat GluN1/GluN2D NMDA receptor complex
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
L-aspartate evoked currents from recombinant rat GluN1/GluN2D receptors expressed in HEK293 cells when glycine was present.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Rat receptor constructs; 1-second 1 mM agonist pulse with 0.05 mM glycine.
- limitations
- This does not demonstrate brain entry, cognitive benefit or excitotoxicity after oral intake.
- nutrient_topic
- L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Aspartate
- plain_language
- L-aspartate can act at a receptor in a controlled electrophysiology experiment.
- primary_references
- Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21522138/ · DOI 10.1038/ncomms1295
L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19) · lines 394–400
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat receptor constructs; 1-second 1 mM agonist pulse with 0.05 mM glycine. · source_derived_draft · unverified_draft
## l-aspartate-nmda-agonism L-aspartate can act at a receptor in a controlled electrophysiology experiment. L-aspartate evoked currents from recombinant rat GluN1/GluN2D receptors expressed in HEK293 cells when glycine was present. Model: Rat receptor constructs; 1-second 1 mM agonist pulse with 0.05 mM glycine. Limitations: This does not demonstrate brain entry, cognitive benefit or excitotoxicity after oral intake. Evidence access: Primary full text Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21522138/ · DOI 10.1038/ncomms1295
Complete structured claim and evidenceL-aspartate-evoked GluN1/GluN2D currents deactivated faster than L-glutamate-evoked currents under matched recording conditions.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Rat recombinant receptors in HEK293 cells; voltage-clamp and structural comparisons.
- limitations
- Not a universal rank of potency or toxicity across all NMDA receptor subtypes.
- nutrient_topic
- L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Aspartate
- plain_language
- Two agonists at the same receptor can produce different signal durations.
- primary_references
- Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21522138/ · DOI 10.1038/ncomms1295
L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19) · lines 402–408
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat recombinant receptors in HEK293 cells; voltage-clamp and structural comparisons. · source_derived_draft · unverified_draft
## l-aspartate-nmda-deactivation Two agonists at the same receptor can produce different signal durations. L-aspartate-evoked GluN1/GluN2D currents deactivated faster than L-glutamate-evoked currents under matched recording conditions. Model: Rat recombinant receptors in HEK293 cells; voltage-clamp and structural comparisons. Limitations: Not a universal rank of potency or toxicity across all NMDA receptor subtypes. Evidence access: Primary full text Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21522138/ · DOI 10.1038/ncomms1295
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.