{"id":"c859cf32-f219-5372-bffa-3a0f551b02b4","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-nmda-deactivation","predicate":"produces_faster_deactivation_than_glutamate","statement":"L-aspartate-evoked GluN1/GluN2D currents deactivated faster than L-glutamate-evoked currents under matched recording conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2ad39b87-8973-5e36-b6c4-248e656e2e7e","mechanism_event_label":"Two agonists at the same receptor can produce different signal durations.","subject":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"fdf3ac1b-d0aa-5ee6-91ea-442e7af6db2b","slug":"rat-grin1-grin2d-receptor","display_name":"Rat GluN1/GluN2D NMDA receptor complex","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"2ad39b87-8973-5e36-b6c4-248e656e2e7e","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-nmda-deactivation-event","event_type":"observed_relationship","label":"Two agonists at the same receptor can produce different signal durations.","description":"L-aspartate-evoked GluN1/GluN2D currents deactivated faster than L-glutamate-evoked currents under matched recording conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fdf3ac1b-d0aa-5ee6-91ea-442e7af6db2b","slug":"rat-grin1-grin2d-receptor","display_name":"Rat GluN1/GluN2D NMDA receptor complex","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat recombinant receptors in HEK293 cells; voltage-clamp and structural comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a universal rank of potency or toxicity across all NMDA receptor subtypes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Two agonists at the same receptor can produce different signal durations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21522138/ · DOI 10.1038/ncomms1295","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f21c335f-6360-5b2b-8e6e-6addb3098bad","evidence_kind":"source_excerpt","locator":"Lines 402-408","start_line":402,"end_line":408,"excerpt":"## l-aspartate-nmda-deactivation\nTwo agonists at the same receptor can produce different signal durations.\nL-aspartate-evoked GluN1/GluN2D currents deactivated faster than L-glutamate-evoked currents under matched recording conditions.\nModel: Rat recombinant receptors in HEK293 cells; voltage-clamp and structural comparisons.\nLimitations: Not a universal rank of potency or toxicity across all NMDA receptor subtypes.\nEvidence access: Primary full text\nLigand-specific deactivation time course of GluN1/GluN2D NMDA receptors. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21522138/ · DOI 10.1038/ncomms1295","model_system":"Rat recombinant receptors in HEK293 cells; voltage-clamp and structural comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"67970dcb-34e0-5b0a-8c86-d8c3cc183444","stable_key":"import-e37461ea-ea5d-5e2c-8091-138305f6dd70","title":"L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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