Component

Rat regional extracellular glutamate

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. At 300 mg/kg, modafinil increased striatal glutamate but not pallidal glutamate; substantia nigra had another response pattern.

    Modafinil → Rat regional extracellular glutamate Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract checked; full methods and figures not comprehensively reviewed.
    experimental_contrast
    {"intervention": "Modafinil 300 mg/kg", "comparator": "Study control", "endpoint": "At 300 mg/kg, modafinil increased striatal glutamate but not pallidal glutamate; substantia nigra had another response pattern.", "effect_direction": "mixed", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Rat regional microdialysis; 300 mg/kg pharmacological exposure, not human therapeutic equivalence.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
    plain_language
    At 300 mg/kg, modafinil increased striatal glutamate but not pallidal glutamate; substantia nigra had another response pattern.
    primary_references
    The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. | 1998 | DOI 10.1016/s0304-3940(98)00629-6 | PMID 9774168 | https://pubmed.ncbi.nlm.nih.gov/9774168/
    source_locator
    Reviewed reference lines 95-95; exact primary location described in quoted passage where extracted.

    Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 95–95

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Rat regional microdialysis; 300 mg/kg pharmacological exposure, not human therapeutic equivalence. · Recorded from source · Recorded from source

    | GABA and glutamate | Rat microdialysis found lower striatal/pallidal GABA at 100 mg/kg, without local glutamate increases. At 300 mg/kg, glutamate rose in striatum but not pallidum; substantia nigra had another response pattern. | Global GABA suppression, global glutamate elevation, direct GABA-receptor antagonism or glutamate-receptor agonism. [1998 study](https://pubmed.ncbi.nlm.nih.gov/9774168/) |
    Complete structured claim and evidence

  2. At 100 mg/kg, modafinil did not increase extracellular glutamate in rat striatum/pallidum.

    Modafinil → Rat regional extracellular glutamate Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract checked; full methods and figures not comprehensively reviewed.
    experimental_contrast
    {"intervention": "Modafinil 100 mg/kg", "comparator": "Study control", "endpoint": "At 100 mg/kg, modafinil did not increase extracellular glutamate in rat striatum/pallidum.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Rat regional microdialysis; 100 mg/kg pharmacological exposure, not human therapeutic equivalence.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
    plain_language
    At 100 mg/kg, modafinil did not increase extracellular glutamate in rat striatum/pallidum.
    primary_references
    The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. | 1998 | DOI 10.1016/s0304-3940(98)00629-6 | PMID 9774168 | https://pubmed.ncbi.nlm.nih.gov/9774168/
    source_locator
    Reviewed reference lines 95-95; exact primary location described in quoted passage where extracted.

    Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 95–95

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Rat regional microdialysis; 100 mg/kg pharmacological exposure, not human therapeutic equivalence. · Recorded from source · Recorded from source

    | GABA and glutamate | Rat microdialysis found lower striatal/pallidal GABA at 100 mg/kg, without local glutamate increases. At 300 mg/kg, glutamate rose in striatum but not pallidum; substantia nigra had another response pattern. | Global GABA suppression, global glutamate elevation, direct GABA-receptor antagonism or glutamate-receptor agonism. [1998 study](https://pubmed.ncbi.nlm.nih.gov/9774168/) |
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.