Component
Rat DRG GABA-activated current in anisatin assays
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Anisatin inhibited GABA-activated current in a use-dependent manner, estimated EC50 1.10 µM.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract reviewed; full results, tables and supplements not independently extracted.
- experimental_contrast
- {"intervention": "Anisatin during GABA activation", "comparator": "GABA activation without anisatin", "endpoint": "Anisatin inhibited GABA-activated current in a use-dependent manner, estimated EC50 1.10 µM.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Rat dorsal-root-ganglion electrophysiology.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Different molecule from shikimic acid; not proof of parent-compound toxicity.
- plain_language
- Anisatin inhibited GABA-activated current in a use-dependent manner, estimated EC50 1.10 µM.
- primary_references
- Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons. | 1999 | DOI 10.1038/sj.bjp.0702700 | PMID 10455311 | https://pubmed.ncbi.nlm.nih.gov/10455311/ | https://doi.org/10.1038/sj.bjp.0702700 | https://pmc.ncbi.nlm.nih.gov/articles/PMC1566146/
- primary_references
- Neurotoxicities in infants seen with the consumption of star anise tea. | 2004 | DOI 10.1542/peds.2004-0058 | PMID 15492355 | https://pubmed.ncbi.nlm.nih.gov/15492355/ | https://doi.org/10.1542/peds.2004-0058
- source_locator
- Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 89–89
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Rat dorsal-root-ganglion electrophysiology. · source_derived_draft · unverified_draft
**Star-anise toxicity is a preparation-identity issue.** Anisatin inhibited GABA-activated currents in rat dorsal-root-ganglion neurons in a use-dependent fashion; an estimated EC50 was 1.10 µM. It is a different molecule from shikimic acid. Seven infant neurological cases associated with star-anise tea and evidence of toxic species contamination demonstrate preparation risk, not toxicity attributable specifically to purified shikimic acid. Botanical identity, plant part, contamination, extraction and measured composition cannot be inferred from the name star anise. [Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons.](https://pubmed.ncbi.nlm.nih.gov/10455311/) [Neurotoxicities in infants seen with the consumption of star anise tea.](https://pubmed.ncbi.nlm.nih.gov/15492355/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.