Component
Rat ceruloplasmin / Cp
Rat ceruloplasmin / Cp. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Very-high-iron feeding caused low serum/tissue copper, reduced circulating ceruloplasmin activity, anemia and cardiac hypertrophy in the studied rats.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/27537180.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "59f2a83f1bffcacfed0df109f3690413aa2e6f08be6ad400817c5cbe2165e523", "start_char": 0, "end_char": 1840, "text_sha256": "59f2a83f1bffcacfed0df109f3690413aa2e6f08be6ad400817c5cbe2165e523"}
- experimental_model
- Five-week factorial iron/copper feeding
- exposure
- Approximately 8800, 80 or 11 ppm iron crossed with approximately 183, 8 or 0.9 ppm copper
- limitations
- Very high experimental iron exposure; not an estimate of human supplement risk at ordinary intake. Copper restoration did not normalize every iron measure.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Weanling male Sprague-Dawley rats
- plain_language
- Anemia developed despite abundant iron because another part of iron handling became deficient.
- primary_references
- [iron-p27537180] High-Iron Consumption Impairs Growth and Causes Copper-Deficiency Anemia in Weanling Sprague-Dawley Rats. (2016). https://pubmed.ncbi.nlm.nih.gov/27537180/ DOI: 10.1371/journal.pone.0161033
- tissue_or_cell_type
- Systemic copper and iron status
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 914–925
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Five-week factorial iron/copper feeding · source_derived_draft · unverified_draft
### iron-high-iron-copper-deficiency Very-high-iron feeding caused low serum/tissue copper, reduced circulating ceruloplasmin activity, anemia and cardiac hypertrophy in the studied rats. Condition category: nutrient_deficiency nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Anemia developed despite abundant iron because another part of iron handling became deficient. organism: Weanling male Sprague-Dawley rats tissue_or_cell_type: Systemic copper and iron status experimental_model: Five-week factorial iron/copper feeding limitations: Very high experimental iron exposure; not an estimate of human supplement risk at ordinary intake. Copper restoration did not normalize every iron measure. exposure: Approximately 8800, 80 or 11 ppm iron crossed with approximately 183, 8 or 0.9 ppm copper evidence_span: {"source_cache": "artifacts/iron-research/27537180.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "59f2a83f1bffcacfed0df109f3690413aa2e6f08be6ad400817c5cbe2165e523", "start_char": 0, "end_char": 1840, "text_sha256": "59f2a83f1bffcacfed0df109f3690413aa2e6f08be6ad400817c5cbe2165e523"} [iron-p27537180] High-Iron Consumption Impairs Growth and Causes Copper-Deficiency Anemia in Weanling Sprague-Dawley Rats. (2016). https://pubmed.ncbi.nlm.nih.gov/27537180/ DOI: 10.1371/journal.pone.0161033
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.