Component
Rat calcium-sensing receptor / Casr
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In rat medullary thyroid carcinoma 6-23 cells, strontium biased CaSR signaling toward ERK1/2 relative to Gq/11 and intracellular-calcium mobilization compared with calcium.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Rat C-cell model; concentration-response measurements across six signaling outputs.
- limitations
- Biased agonism is model- and assay-dependent; not a direct human thyroid-hormone effect.
- nutrient_topic
- Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
- plain_language
- The same receptor can send different relative signals depending on the ion.
- primary_references
- Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22942242/ · DOI 10.1124/jpet.112.197210
Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 342–348
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat C-cell model; concentration-response measurements across six signaling outputs. · source_derived_draft · unverified_draft
## strontium-thyroid-bias The same receptor can send different relative signals depending on the ion. In rat medullary thyroid carcinoma 6-23 cells, strontium biased CaSR signaling toward ERK1/2 relative to Gq/11 and intracellular-calcium mobilization compared with calcium. Model: Rat C-cell model; concentration-response measurements across six signaling outputs. Limitations: Biased agonism is model- and assay-dependent; not a direct human thyroid-hormone effect. Evidence access: Primary abstract Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22942242/ · DOI 10.1124/jpet.112.197210
Complete structured claim and evidence
Where it participates (unsigned role)
Strontium stimulated calcitonin secretion with higher potency than calcium in the rat 6-23 cell study despite differing signaling bias.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Rat medullary thyroid carcinoma cell concentration-response assays.
- limitations
- Calcitonin is not T3/T4, and this does not establish the net human calcium response.
- nutrient_topic
- Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
- plain_language
- A calcium-like ion can affect a hormone involved in calcium regulation.
- primary_references
- Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22942242/ · DOI 10.1124/jpet.112.197210
Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 350–356
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat medullary thyroid carcinoma cell concentration-response assays. · source_derived_draft · unverified_draft
## strontium-calcitonin-secretion A calcium-like ion can affect a hormone involved in calcium regulation. Strontium stimulated calcitonin secretion with higher potency than calcium in the rat 6-23 cell study despite differing signaling bias. Model: Rat medullary thyroid carcinoma cell concentration-response assays. Limitations: Calcitonin is not T3/T4, and this does not establish the net human calcium response. Evidence access: Primary abstract Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22942242/ · DOI 10.1124/jpet.112.197210
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.