{"id":"d2147eaa-ced5-595c-93f3-20fb2ce1a893","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-calcitonin-secretion","predicate":"stimulates","statement":"Strontium stimulated calcitonin secretion with higher potency than calcium in the rat 6-23 cell study despite differing signaling bias.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4a2398b4-46ba-5de9-aab1-4b11903413c2","mechanism_event_label":"A calcium-like ion can affect a hormone involved in calcium regulation.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"4fbf0a4e-3ea9-5e1a-8eea-5a9ac62bb868","slug":"rat-thyroid-cell-calcitonin-secretion","display_name":"Calcitonin secretion by rat thyroid 6-23 cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4a2398b4-46ba-5de9-aab1-4b11903413c2","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-calcitonin-secretion-event","event_type":"observed_relationship","label":"A calcium-like ion can affect a hormone involved in calcium regulation.","description":"Strontium stimulated calcitonin secretion with higher potency than calcium in the rat 6-23 cell study despite differing signaling bias.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4fbf0a4e-3ea9-5e1a-8eea-5a9ac62bb868","slug":"rat-thyroid-cell-calcitonin-secretion","display_name":"Calcitonin secretion by rat thyroid 6-23 cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"67c9319b-f42a-5b79-807f-8009a5401245","slug":"rat-casr","display_name":"Rat calcium-sensing receptor / Casr","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat medullary thyroid carcinoma cell concentration-response assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Calcitonin is not T3/T4, and this does not establish the net human calcium response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A calcium-like ion can affect a hormone involved in calcium regulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22942242/ · DOI 10.1124/jpet.112.197210","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f6a8a1cf-c5d3-55d0-ad4a-0cc75cb137b2","evidence_kind":"source_excerpt","locator":"Lines 350-356","start_line":350,"end_line":356,"excerpt":"## strontium-calcitonin-secretion\nA calcium-like ion can affect a hormone involved in calcium regulation.\nStrontium stimulated calcitonin secretion with higher potency than calcium in the rat 6-23 cell study despite differing signaling bias.\nModel: Rat medullary thyroid carcinoma cell concentration-response assays.\nLimitations: Calcitonin is not T3/T4, and this does not establish the net human calcium response.\nEvidence access: Primary abstract\nStrontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22942242/ · DOI 10.1124/jpet.112.197210","model_system":"Rat medullary thyroid carcinoma cell concentration-response assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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