Component
Rat AMPA-type glutamate receptors, subunits unresolved
Rat AMPA-type glutamate receptors, subunits unresolved. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
An AMPA antagonist inhibited the local neurotransmitter effects attributed to theanine.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/theanine-research/18196445.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "59fdaf94d59c2f4b2981c29cd2981c043351aae1299a59a19e29979076957839", "start_char": 0, "end_char": 1118, "text_sha256": "59fdaf94d59c2f4b2981c29cd2981c043351aae1299a59a19e29979076957839"}
- experimental_model
- In-vivo striatal microdialysis with receptor antagonists
- exposure
- Local brain theanine administration; glycine and AMPA antagonists
- limitations
- Direct brain dosing bypasses oral absorption and blood-brain-barrier transport. Antagonist sensitivity identifies pathway involvement, not necessarily direct theanine binding.
- nutrient_topic
- L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
- organism
- Conscious rats
- plain_language
- Another receptor family affected the response; this is not evidence of a universal dopamine increase.
- primary_references
- [theanine-p18196445] Theanine, gamma-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. (2009). https://pubmed.ncbi.nlm.nih.gov/18196445/ DOI: 10.1007/s00726-007-0020-7
- tissue_or_cell_type
- Striatal extracellular neurotransmitters
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 393–404
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · In-vivo striatal microdialysis with receptor antagonists · source_derived_draft · unverified_draft
### theanine-ampa-striatum An AMPA antagonist inhibited the local neurotransmitter effects attributed to theanine. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Another receptor family affected the response; this is not evidence of a universal dopamine increase. organism: Conscious rats tissue_or_cell_type: Striatal extracellular neurotransmitters experimental_model: In-vivo striatal microdialysis with receptor antagonists limitations: Direct brain dosing bypasses oral absorption and blood-brain-barrier transport. Antagonist sensitivity identifies pathway involvement, not necessarily direct theanine binding. exposure: Local brain theanine administration; glycine and AMPA antagonists evidence_span: {"source_cache": "artifacts/theanine-research/18196445.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "59fdaf94d59c2f4b2981c29cd2981c043351aae1299a59a19e29979076957839", "start_char": 0, "end_char": 1118, "text_sha256": "59fdaf94d59c2f4b2981c29cd2981c043351aae1299a59a19e29979076957839"} [theanine-p18196445] Theanine, gamma-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. (2009). https://pubmed.ncbi.nlm.nih.gov/18196445/ DOI: 10.1007/s00726-007-0020-7
Complete structured claim and evidence
What acts on it
Theanine inhibited radioligand binding at AMPA sites in rat cortical preparations.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/theanine-research/12596867.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "eaa387f7967a1ff8e68eceb71fd3294881967066c5dc080fd27bacf8a01ce33d", "start_char": 0, "end_char": 643, "text_sha256": "eaa387f7967a1ff8e68eceb71fd3294881967066c5dc080fd27bacf8a01ce33d"}
- experimental_model
- Radioligand receptor-binding competition
- exposure
- Theanine competition with radiolabeled ligands
- limitations
- Binding displacement is not proof of functional agonism/antagonism at an oral human dose. Abstract wording for the 80-30000-fold IC50 comparison is ambiguous and is not used as a potency estimate.
- nutrient_topic
- L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
- organism
- Rat cortical preparations
- plain_language
- A binding assay identifies a possible receptor interaction while leaving functional and clinical effects unresolved.
- primary_references
- [theanine-p12596867] Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. (2002). https://pubmed.ncbi.nlm.nih.gov/12596867/ DOI: 10.1271/bbb.66.2683
- tissue_or_cell_type
- AMPA, kainate and NMDA glycine-site binding
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 289–300
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radioligand receptor-binding competition · source_derived_draft · unverified_draft
### theanine-binding-ampa Theanine inhibited radioligand binding at AMPA sites in rat cortical preparations. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A binding assay identifies a possible receptor interaction while leaving functional and clinical effects unresolved. organism: Rat cortical preparations tissue_or_cell_type: AMPA, kainate and NMDA glycine-site binding experimental_model: Radioligand receptor-binding competition limitations: Binding displacement is not proof of functional agonism/antagonism at an oral human dose. Abstract wording for the 80-30000-fold IC50 comparison is ambiguous and is not used as a potency estimate. exposure: Theanine competition with radiolabeled ligands evidence_span: {"source_cache": "artifacts/theanine-research/12596867.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "eaa387f7967a1ff8e68eceb71fd3294881967066c5dc080fd27bacf8a01ce33d", "start_char": 0, "end_char": 643, "text_sha256": "eaa387f7967a1ff8e68eceb71fd3294881967066c5dc080fd27bacf8a01ce33d"} [theanine-p12596867] Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. (2002). https://pubmed.ncbi.nlm.nih.gov/12596867/ DOI: 10.1271/bbb.66.2683
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.