Component
Human Epac1 / RAPGEF3
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Epac1 siRNA, unlike PKA catalytic-subunit siRNA, blocked resveratrol-induced AMPK/ACC phosphorylation in human HeLa cells.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- HeLa experiments selected to avoid myogenesis confounding; 50 micromolar resveratrol.
- limitations
- RNAi does not make all tissue responses Epac1-dependent.
- nutrient_topic
- Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Resveratrol
- plain_language
- A cAMP effector is a tested dependency.
- primary_references
- Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19) · lines 238–244
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · HeLa experiments selected to avoid myogenesis confounding; 50 micromolar resveratrol. · source_derived_draft · unverified_draft
## resveratrol-epac-loss A cAMP effector is a tested dependency. Epac1 siRNA, unlike PKA catalytic-subunit siRNA, blocked resveratrol-induced AMPK/ACC phosphorylation in human HeLa cells. Model: HeLa experiments selected to avoid myogenesis confounding; 50 micromolar resveratrol. Limitations: RNAi does not make all tissue responses Epac1-dependent. Evidence access: Primary full text Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017
Complete structured claim and evidenceEpac1 siRNA prevented the resveratrol-induced NAD increase and PGC-1alpha deacetylation in human HeLa experiments.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Same cellular mechanism study.
- limitations
- NAD measurement and substrate deacetylation do not establish direct SIRT1 binding.
- nutrient_topic
- Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Resveratrol
- plain_language
- Calcium/cAMP signaling connects to NAD-dependent regulation.
- primary_references
- Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19) · lines 246–252
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Same cellular mechanism study. · source_derived_draft · unverified_draft
## resveratrol-epac-nad-loss Calcium/cAMP signaling connects to NAD-dependent regulation. Epac1 siRNA prevented the resveratrol-induced NAD increase and PGC-1alpha deacetylation in human HeLa experiments. Model: Same cellular mechanism study. Limitations: NAD measurement and substrate deacetylation do not establish direct SIRT1 binding. Evidence access: Primary full text Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.