Component
Rabbit creatine transporter / Slc6a8
Rabbit creatine transporter / Slc6a8. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The cloned rabbit creatine transporter mediated sodium- and chloride-dependent creatine uptake, with an apparent Km of approximately 35 micromolar.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/8473283.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "10a3e9e18054bc80e38fe289f59ba358853482082e69c87af0844ac90a6da5c7", "start_char": 0, "end_char": 1330, "text_sha256": "10a3e9e18054bc80e38fe289f59ba358853482082e69c87af0844ac90a6da5c7"}
- experimental_model
- Rabbit transporter cloning and heterologous uptake assay
- exposure
- Radiolabeled creatine uptake with ion dependence and substrate analogues
- limitations
- Rabbit expression assay; neither human ion stoichiometry nor a benefit from extra dietary salt is inferred.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- Rabbit transporter expressed in COS-7 cells
- plain_language
- Creatine uptake used both sodium and chloride in this transport experiment.
- primary_references
- [creatine-p8473283] A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression. (1993). https://pubmed.ncbi.nlm.nih.gov/8473283/ DOI: 10.1016/s0021-9258(18)52891-x
- tissue_or_cell_type
- Cell plasma membrane
- transport_effect
- raises Sodium- and chloride-dependent creatine uptake with an apparent Km near 35 micromolar.
- transport_pool
- the expressing cell Sodium- and chloride-dependent creatine uptake with an apparent Km near 35 micromolar.
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 412–423
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rabbit transporter cloning and heterologous uptake assay · source_derived_draft · unverified_draft
### creatine-rabbit-sodium-chloride The cloned rabbit creatine transporter mediated sodium- and chloride-dependent creatine uptake, with an apparent Km of approximately 35 micromolar. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Creatine uptake used both sodium and chloride in this transport experiment. organism: Rabbit transporter expressed in COS-7 cells tissue_or_cell_type: Cell plasma membrane experimental_model: Rabbit transporter cloning and heterologous uptake assay limitations: Rabbit expression assay; neither human ion stoichiometry nor a benefit from extra dietary salt is inferred. exposure: Radiolabeled creatine uptake with ion dependence and substrate analogues evidence_span: {"source_cache": "artifacts/creatine-research/8473283.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "10a3e9e18054bc80e38fe289f59ba358853482082e69c87af0844ac90a6da5c7", "start_char": 0, "end_char": 1330, "text_sha256": "10a3e9e18054bc80e38fe289f59ba358853482082e69c87af0844ac90a6da5c7"} [creatine-p8473283] A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression. (1993). https://pubmed.ncbi.nlm.nih.gov/8473283/ DOI: 10.1016/s0021-9258(18)52891-x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.