Component

Rabbit calcium-sensing receptor / CaSR

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Combining extracellular strontium and calcium produced greater apoptosis of mature rabbit osteoclasts than either ion alone.

    Strontium ion / Sr2+ → Apoptosis of mature rabbit osteoclasts source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary rabbit osteoclast combination experiment.
    limitations
    Greater combined effect is not proof of clinical synergy, an optimal ratio or a supplement recommendation.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    A measured interaction between the two ions is preserved as its own finding.
    primary_references
    The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 238–244

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary rabbit osteoclast combination experiment. · source_derived_draft · unverified_draft

    ## strontium-calcium-combination A measured interaction between the two ions is preserved as its own finding. Combining extracellular strontium and calcium produced greater apoptosis of mature rabbit osteoclasts than either ion alone. Model: Primary rabbit osteoclast combination experiment. Limitations: Greater combined effect is not proof of clinical synergy, an optimal ratio or a supplement recommendation. Evidence access: Primary abstract The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200
    Complete structured claim and evidence

  2. Strontium dose-dependently induced apoptosis of primary mature rabbit osteoclasts through a CaSR-linked pathway.

    Strontium ion / Sr2+ → Apoptosis of mature rabbit osteoclasts source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary mature rabbit osteoclast study.
    limitations
    Species and high experimental exposures limit translation to human dietary intake.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    In this model, the ion can promote death of bone-resorbing cells.
    primary_references
    The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 214–220

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary mature rabbit osteoclast study. · source_derived_draft · unverified_draft

    ## strontium-rabbit-apoptosis In this model, the ion can promote death of bone-resorbing cells. Strontium dose-dependently induced apoptosis of primary mature rabbit osteoclasts through a CaSR-linked pathway. Model: Primary mature rabbit osteoclast study. Limitations: Species and high experimental exposures limit translation to human dietary intake. Evidence access: Primary abstract The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200
    Complete structured claim and evidence

  3. Strontium-induced rabbit osteoclast apoptosis required PLC-dependent signaling and PKC beta II activation, with nuclear NF-kappaB translocation.

    Strontium ion / Sr2+ → Rabbit protein kinase C beta II source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Rabbit mature-osteoclast signaling and inhibitor experiments.
    limitations
    Accessed abstract does not resolve PLC or NF-kappaB subunits; do not assign human proteins.
    nutrient_topic
    Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Strontium
    plain_language
    The shared calcium sensor can use a distinct downstream pathway.
    primary_references
    The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200

    Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19) · lines 222–228

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rabbit mature-osteoclast signaling and inhibitor experiments. · source_derived_draft · unverified_draft

    ## strontium-rabbit-plc-pkc The shared calcium sensor can use a distinct downstream pathway. Strontium-induced rabbit osteoclast apoptosis required PLC-dependent signaling and PKC beta II activation, with nuclear NF-kappaB translocation. Model: Rabbit mature-osteoclast signaling and inhibitor experiments. Limitations: Accessed abstract does not resolve PLC or NF-kappaB subunits; do not assign human proteins. Evidence access: Primary abstract The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards