{"id":"5c9b6d56-f898-5e0f-a8f3-b86187a3aa85","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-rabbit-apoptosis","predicate":"induces","statement":"Strontium dose-dependently induced apoptosis of primary mature rabbit osteoclasts through a CaSR-linked pathway.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6317d7a1-10d3-57eb-bd71-2886cf025313","mechanism_event_label":"In this model, the ion can promote death of bone-resorbing cells.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"35aba475-0d0e-5063-8ccc-a93f3e4638e2","slug":"rabbit-mature-osteoclast-apoptosis","display_name":"Apoptosis of mature rabbit osteoclasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6317d7a1-10d3-57eb-bd71-2886cf025313","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-rabbit-apoptosis-event","event_type":"observed_relationship","label":"In this model, the ion can promote death of bone-resorbing cells.","description":"Strontium dose-dependently induced apoptosis of primary mature rabbit osteoclasts through a CaSR-linked pathway.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"35aba475-0d0e-5063-8ccc-a93f3e4638e2","slug":"rabbit-mature-osteoclast-apoptosis","display_name":"Apoptosis of mature rabbit osteoclasts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bc93fef2-780a-5e1d-b4c7-24a087c7581b","slug":"rabbit-casr","display_name":"Rabbit calcium-sensing receptor / CaSR","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary mature rabbit osteoclast study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Species and high experimental exposures limit translation to human dietary intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"In this model, the ion can promote death of bone-resorbing cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0ca2d806-d798-5540-bd1b-00131ef9d988","evidence_kind":"source_excerpt","locator":"Lines 214-220","start_line":214,"end_line":220,"excerpt":"## strontium-rabbit-apoptosis\nIn this model, the ion can promote death of bone-resorbing cells.\nStrontium dose-dependently induced apoptosis of primary mature rabbit osteoclasts through a CaSR-linked pathway.\nModel: Primary mature rabbit osteoclast study.\nLimitations: Species and high experimental exposures limit translation to human dietary intake.\nEvidence access: Primary abstract\nThe calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200","model_system":"Primary mature rabbit osteoclast study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"51221949263cdf8a22a79c32e3989599de1a37dc215700e0a076f436b40a1005","revision_id":"84f6df49-c456-5ad2-8214-cc69d5dc7722","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}