Component

Rosmarinic-acid auto-oxidation products, mixture unresolved

Rosmarinic-acid auto-oxidation products, mixture unresolved

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Preincubating bovine TSH with RA oxidation products reduced its activity in the mouse bioassay.

    Rosmarinic-acid auto-oxidation products, mixture unresolved → TSH bioactivity in the McKenzie mouse assay Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
    experimental_contrast
    {"intervention": "Hormone preincubated with oxidized RA", "comparator": "Untreated hormone", "endpoint": "Preincubating bovine TSH with RA oxidation products reduced its activity in the mouse bioassay.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; recorded from source.
    experimental_model
    Preincubation assay; not a controlled human oral RA trial.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Rosmarinic acid collection; exact intervention and molecular form govern interpretation. · Rosmarinic acid
    plain_language
    Preincubating bovine TSH with RA oxidation products reduced its activity in the mouse bioassay.
    primary_references
    The active principles of plant extracts with antithyrotropic activity: oxidation products of derivatives of 3,4-dihydroxycinnamic acid. | https://pubmed.ncbi.nlm.nih.gov/3987612/ | https://doi.org/10.1210/endo-116-5-1677
    source_locator
    Reviewed reference ra-thyroid-bioassay; This does not establish hypothyroidism or interference with levothyroxine treatment.

    Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026) · lines 510–516

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Preincubation assay; not a controlled human oral RA trial. · Recorded from source · Recorded from source

    ### ra-thyroid-bioassay Preincubating bovine TSH with RA oxidation products reduced its activity in the mouse bioassay. This does not establish hypothyroidism or interference with levothyroxine treatment. Model and exposure: Preincubation assay; not a controlled human oral RA trial. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: The active principles of plant extracts with antithyrotropic activity: oxidation products of derivatives of 3,4-dihydroxycinnamic acid. | 1985 | https://pubmed.ncbi.nlm.nih.gov/3987612/ | https://doi.org/10.1210/endo-116-5-1677 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
    Complete structured claim and evidence

  2. RA auto-oxidation products inhibited bovine-TSH binding to human thyroid membranes.

    Rosmarinic-acid auto-oxidation products, mixture unresolved → Human thyrotropin receptor / TSHR Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
    experimental_contrast
    {"intervention": "Auto-oxidized RA with bovine TSH", "comparator": "Hormone without oxidized compound", "endpoint": "RA auto-oxidation products inhibited bovine-TSH binding to human thyroid membranes.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; recorded from source.
    experimental_model
    1985 cell-free hormone-binding study; oxidation-product mixtures.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Rosmarinic acid collection; exact intervention and molecular form govern interpretation. · Rosmarinic acid
    plain_language
    RA auto-oxidation products inhibited bovine-TSH binding to human thyroid membranes.
    primary_references
    The active principles of plant extracts with antithyrotropic activity: oxidation products of derivatives of 3,4-dihydroxycinnamic acid. | https://pubmed.ncbi.nlm.nih.gov/3987612/ | https://doi.org/10.1210/endo-116-5-1677
    source_locator
    Reviewed reference ra-thyroid-oxidized; Across eight active compounds, half-inhibition required products equivalent to 20–80 micrograms/mL starting compound. No RA-specific universal clinical threshold.

    Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026) · lines 494–500

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · 1985 cell-free hormone-binding study; oxidation-product mixtures. · Recorded from source · Recorded from source

    ### ra-thyroid-oxidized RA auto-oxidation products inhibited bovine-TSH binding to human thyroid membranes. Across eight active compounds, half-inhibition required products equivalent to 20–80 micrograms/mL starting compound. No RA-specific universal clinical threshold. Model and exposure: 1985 cell-free hormone-binding study; oxidation-product mixtures. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: The active principles of plant extracts with antithyrotropic activity: oxidation products of derivatives of 3,4-dihydroxycinnamic acid. | 1985 | https://pubmed.ncbi.nlm.nih.gov/3987612/ | https://doi.org/10.1210/endo-116-5-1677 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.