Component
Quantitative sensory thresholds
Independently recorded entity or measured process. Linked claims specify compartment, assay and experimental scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Thermal thresholds changed before or more strongly than vibration thresholds in the lower-dose group; sensory nerve-potential changes lagged thresholds in two of three subjects.
Experimental context and source evidence
- experimental_model
- Five healthy volunteers prospectively followed during experimental pyridoxine excess.
- exposure
- Pyridoxine 1 or 3 g/day, stopped with clinical/laboratory abnormality; very high historical exposures.
- limitations
- Small experimental groups; not a diagnostic screening protocol.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- Different nerve tests detected the developing injury at different times.
- primary_references
- [b6-berger1992] Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity (1992). https://pubmed.ncbi.nlm.nih.gov/1620347/ DOI: 10.1212/wnl.42.7.1367
- tissue_or_cell_type
- Peripheral sensory nerve function
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1572–1582
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Five healthy volunteers prospectively followed during experimental pyridoxine excess. · source_derived_draft · unverified_draft
### b6-toxicity-early-sensory-tests Thermal thresholds changed before or more strongly than vibration thresholds in the lower-dose group; sensory nerve-potential changes lagged thresholds in two of three subjects. Condition category: normal nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Different nerve tests detected the developing injury at different times. organism: Homo sapiens tissue_or_cell_type: Peripheral sensory nerve function experimental_model: Five healthy volunteers prospectively followed during experimental pyridoxine excess. limitations: Small experimental groups; not a diagnostic screening protocol. exposure: Pyridoxine 1 or 3 g/day, stopped with clinical/laboratory abnormality; very high historical exposures. [b6-berger1992] Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity (1992). https://pubmed.ncbi.nlm.nih.gov/1620347/ DOI: 10.1212/wnl.42.7.1367
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.