{"id":"45e3f36b-1564-595f-91db-6f986ef242c8","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-toxicity-early-sensory-tests","predicate":"high_exposure_altered_sensory_thresholds","statement":"Thermal thresholds changed before or more strongly than vibration thresholds in the lower-dose group; sensory nerve-potential changes lagged thresholds in two of three subjects.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0fe4d71c-7fbe-5e47-86d9-a8951a563f16","mechanism_event_label":"Different nerve tests detected the developing injury at different times.","subject":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"object":{"id":"ed09eb24-e57b-5dc0-8ee4-3a174630cb00","slug":"quantitative-sensory-thresholds","display_name":"Quantitative sensory thresholds","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0fe4d71c-7fbe-5e47-86d9-a8951a563f16","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-toxicity-early-sensory-tests-event","event_type":"observed_intervention","label":"Different nerve tests detected the developing injury at different times.","description":"Thermal thresholds changed before or more strongly than vibration thresholds in the lower-dose group; sensory nerve-potential changes lagged thresholds in two of three subjects.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d728b2a6-7e08-5036-b13b-620ad1b8e171","slug":"sensory-nerve-action-potentials","display_name":"Sensory nerve action potentials","entity_type_key":"cellular_process"},"role":"other_test","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ed09eb24-e57b-5dc0-8ee4-3a174630cb00","slug":"quantitative-sensory-thresholds","display_name":"Quantitative sensory thresholds","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Five healthy volunteers prospectively followed during experimental pyridoxine excess.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Pyridoxine 1 or 3 g/day, stopped with clinical/laboratory abnormality; very high historical exposures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small experimental groups; not a diagnostic screening protocol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Different nerve tests detected the developing injury at different times.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-berger1992] Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity (1992). https://pubmed.ncbi.nlm.nih.gov/1620347/ DOI: 10.1212/wnl.42.7.1367","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Peripheral sensory nerve function","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"88da4c35-895b-5460-82bb-ab81107c0f86","evidence_kind":"source_excerpt","locator":"Lines 1572-1582","start_line":1572,"end_line":1582,"excerpt":"### b6-toxicity-early-sensory-tests\nThermal thresholds changed before or more strongly than vibration thresholds in the lower-dose group; sensory nerve-potential changes lagged thresholds in two of three subjects.\nCondition category: normal\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Different nerve tests detected the developing injury at different times.\norganism: Homo sapiens\ntissue_or_cell_type: Peripheral sensory nerve function\nexperimental_model: Five healthy volunteers prospectively followed during experimental pyridoxine excess.\nlimitations: Small experimental groups; not a diagnostic screening protocol.\nexposure: Pyridoxine 1 or 3 g/day, stopped with clinical/laboratory abnormality; very high historical exposures.\n[b6-berger1992] Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity (1992). https://pubmed.ncbi.nlm.nih.gov/1620347/ DOI: 10.1212/wnl.42.7.1367","model_system":"Five healthy volunteers prospectively followed during experimental pyridoxine excess.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-berger1992] Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity (1992). https://pubmed.ncbi.nlm.nih.gov/1620347/ DOI: 10.1212/wnl.42.7.1367","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}