Component

PTP1B preparation in 2017 inhibition study, species not resolved from abstract

PTP1B preparation in 2017 inhibition study, species not resolved from abstract. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

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How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. CGA showed noncompetitive PTP1B inhibition in the combined kinetic and NMR investigation.

    Chlorogenic acid / 5-O-caffeoylquinic acid → PTP1B preparation in 2017 inhibition study, species not resolved from abstract source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/27959494.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4f4610d35c42975e3cc1026d2daa4014952bc442a58e711b430db873d22a7475", "start_char": 0, "end_char": 1044, "text_sha256": "4f4610d35c42975e3cc1026d2daa4014952bc442a58e711b430db873d22a7475"}
    experimental_model
    Steady-state kinetics, solution NMR and molecular dynamics
    exposure
    CGA compared with cichoric acid; quantitative assay regimen not given in abstract
    limitations
    Do not merge species-unresolved preparation with human or rodent PTPN1. An enzyme assay does not establish clinical insulin sensitization; simulated hydrogen-bond changes are a proposed mechanism.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Purified PTP1B preparation; species not specified in indexed abstract
    plain_language
    An insulin-pathway regulator is a biochemical target candidate.
    primary_references
    [chlorogenic_acid-p27959494] Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid. (2017). https://pubmed.ncbi.nlm.nih.gov/27959494/ DOI: 10.1021/acs.biochem.6b01025
    tissue_or_cell_type
    Enzyme inhibition and binding-site analysis

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 516–527

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Steady-state kinetics, solution NMR and molecular dynamics · source_derived_draft · unverified_draft

    ### chlorogenic_acid-ptp1b-inhibition CGA showed noncompetitive PTP1B inhibition in the combined kinetic and NMR investigation. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: An insulin-pathway regulator is a biochemical target candidate. organism: Purified PTP1B preparation; species not specified in indexed abstract tissue_or_cell_type: Enzyme inhibition and binding-site analysis experimental_model: Steady-state kinetics, solution NMR and molecular dynamics limitations: Do not merge species-unresolved preparation with human or rodent PTPN1. An enzyme assay does not establish clinical insulin sensitization; simulated hydrogen-bond changes are a proposed mechanism. exposure: CGA compared with cichoric acid; quantitative assay regimen not given in abstract evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/27959494.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4f4610d35c42975e3cc1026d2daa4014952bc442a58e711b430db873d22a7475", "start_char": 0, "end_char": 1044, "text_sha256": "4f4610d35c42975e3cc1026d2daa4014952bc442a58e711b430db873d22a7475"} [chlorogenic_acid-p27959494] Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid. (2017). https://pubmed.ncbi.nlm.nih.gov/27959494/ DOI: 10.1021/acs.biochem.6b01025
    Complete structured claim and evidence

  2. The observed CGA binding site was the second aryl-phosphate site, rather than the previously docked benzofuran pocket.

    Chlorogenic acid / 5-O-caffeoylquinic acid → PTP1B preparation in 2017 inhibition study, species not resolved from abstract source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/27959494.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4f4610d35c42975e3cc1026d2daa4014952bc442a58e711b430db873d22a7475", "start_char": 0, "end_char": 1044, "text_sha256": "4f4610d35c42975e3cc1026d2daa4014952bc442a58e711b430db873d22a7475"}
    experimental_model
    Steady-state kinetics, solution NMR and molecular dynamics
    exposure
    CGA compared with cichoric acid; quantitative assay regimen not given in abstract
    limitations
    Do not merge species-unresolved preparation with human or rodent PTPN1. An enzyme assay does not establish clinical insulin sensitization; simulated hydrogen-bond changes are a proposed mechanism.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Purified PTP1B preparation; species not specified in indexed abstract
    plain_language
    Experimental localization refines the earlier prediction; this is not an unresolved biological contradiction.
    primary_references
    [chlorogenic_acid-p27959494] Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid. (2017). https://pubmed.ncbi.nlm.nih.gov/27959494/ DOI: 10.1021/acs.biochem.6b01025
    tissue_or_cell_type
    Enzyme inhibition and binding-site analysis

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 529–540

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Steady-state kinetics, solution NMR and molecular dynamics · source_derived_draft · unverified_draft

    ### chlorogenic_acid-ptp1b-site The observed CGA binding site was the second aryl-phosphate site, rather than the previously docked benzofuran pocket. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Experimental localization refines the earlier prediction; this is not an unresolved biological contradiction. organism: Purified PTP1B preparation; species not specified in indexed abstract tissue_or_cell_type: Enzyme inhibition and binding-site analysis experimental_model: Steady-state kinetics, solution NMR and molecular dynamics limitations: Do not merge species-unresolved preparation with human or rodent PTPN1. An enzyme assay does not establish clinical insulin sensitization; simulated hydrogen-bond changes are a proposed mechanism. exposure: CGA compared with cichoric acid; quantitative assay regimen not given in abstract evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/27959494.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4f4610d35c42975e3cc1026d2daa4014952bc442a58e711b430db873d22a7475", "start_char": 0, "end_char": 1044, "text_sha256": "4f4610d35c42975e3cc1026d2daa4014952bc442a58e711b430db873d22a7475"} [chlorogenic_acid-p27959494] Characterization of Protein Tyrosine Phosphatase 1B Inhibition by Chlorogenic Acid and Cichoric Acid. (2017). https://pubmed.ncbi.nlm.nih.gov/27959494/ DOI: 10.1021/acs.biochem.6b01025
    Complete structured claim and evidence

In the sources

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    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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