Component
Prostate cancer mortality
Prostate cancer mortality. Read linked claims for the population, experiment and limits.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Prostate-cancer mortality was 41% lower in ATBC participants assigned alpha-tocopherol, with a reported confidence interval extending from a 65% to a 1% reduction.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69
- exposure
- Alpha-tocopherol 50 mg/day with or without beta-carotene 20 mg/day; median 6.1 years.
- limitations
- Secondary cancer endpoint in male smokers; differs from SELECT in dose, population and ascertainment. An opposite trial result is not automatically a same-condition biological contradiction.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- The smoker trial also reported fewer prostate-cancer deaths, with substantial uncertainty around the estimate.
- primary_references
- [e-clin-atbc1998] Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. (1998). https://pubmed.ncbi.nlm.nih.gov/9521168/ DOI: 10.1093/jnci/90.6.440
- tissue_or_cell_type
- Prostate and whole-person outcomes
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1336–1347
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69 · source_derived_draft · unverified_draft
### e-clin-atbc-prostate-mortality Prostate-cancer mortality was 41% lower in ATBC participants assigned alpha-tocopherol, with a reported confidence interval extending from a 65% to a 1% reduction. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: The smoker trial also reported fewer prostate-cancer deaths, with substantial uncertainty around the estimate. organism: Homo sapiens tissue_or_cell_type: Prostate and whole-person outcomes experimental_model: ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69 limitations: Secondary cancer endpoint in male smokers; differs from SELECT in dose, population and ascertainment. An opposite trial result is not automatically a same-condition biological contradiction. exposure: Alpha-tocopherol 50 mg/day with or without beta-carotene 20 mg/day; median 6.1 years. cross_nutrient: false [e-clin-atbc1998] Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. (1998). https://pubmed.ncbi.nlm.nih.gov/9521168/ DOI: 10.1093/jnci/90.6.440
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.