{"id":"5fb8ab32-42da-53fe-b1ed-4262269368c5","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-atbc-prostate-mortality","predicate":"reduces_observed","statement":"Prostate-cancer mortality was 41% lower in ATBC participants assigned alpha-tocopherol, with a reported confidence interval extending from a 65% to a 1% reduction.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"44b4696e-7559-5c29-9e3e-8ff2adf1d8f7","mechanism_event_label":"The smoker trial also reported fewer prostate-cancer deaths, with substantial uncertainty around the estimate.","subject":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"object":{"id":"e44b1244-6d6c-5960-b5a5-40cd296389cf","slug":"prostate-cancer-mortality","display_name":"Prostate cancer mortality","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"44b4696e-7559-5c29-9e3e-8ff2adf1d8f7","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-atbc-prostate-mortality-event","event_type":"observed_intervention","label":"The smoker trial also reported fewer prostate-cancer deaths, with substantial uncertainty around the estimate.","description":"Prostate-cancer mortality was 41% lower in ATBC participants assigned alpha-tocopherol, with a reported confidence interval extending from a 65% to a 1% reduction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"73c24cd4-9ae8-5897-8359-fa4d9e8edecb","slug":"beta-carotene","display_name":"All-trans-beta-carotene","entity_type_key":"small_molecule"},"role":"factorial_trial_agent","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e44b1244-6d6c-5960-b5a5-40cd296389cf","slug":"prostate-cancer-mortality","display_name":"Prostate cancer mortality","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Alpha-tocopherol 50 mg/day with or without beta-carotene 20 mg/day; median 6.1 years.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Secondary cancer endpoint in male smokers; differs from SELECT in dose, population and ascertainment. An opposite trial result is not automatically a same-condition biological contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The smoker trial also reported fewer prostate-cancer deaths, with substantial uncertainty around the estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-atbc1998] Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. (1998). https://pubmed.ncbi.nlm.nih.gov/9521168/ DOI: 10.1093/jnci/90.6.440","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Prostate and whole-person outcomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a7c2c403-c675-52d5-a8c9-eb37b63c5f75","evidence_kind":"source_excerpt","locator":"Lines 1336-1347","start_line":1336,"end_line":1347,"excerpt":"### e-clin-atbc-prostate-mortality\nProstate-cancer mortality was 41% lower in ATBC participants assigned alpha-tocopherol, with a reported confidence interval extending from a 65% to a 1% reduction.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The smoker trial also reported fewer prostate-cancer deaths, with substantial uncertainty around the estimate.\norganism: Homo sapiens\ntissue_or_cell_type: Prostate and whole-person outcomes\nexperimental_model: ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69\nlimitations: Secondary cancer endpoint in male smokers; differs from SELECT in dose, population and ascertainment. An opposite trial result is not automatically a same-condition biological contradiction.\nexposure: Alpha-tocopherol 50 mg/day with or without beta-carotene 20 mg/day; median 6.1 years.\ncross_nutrient: false\n[e-clin-atbc1998] Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. (1998). https://pubmed.ncbi.nlm.nih.gov/9521168/ DOI: 10.1093/jnci/90.6.440","model_system":"ATBC randomized factorial trial secondary prostate-cancer endpoint; 29133 Finnish male smokers aged 50–69","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-atbc1998] Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. 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