Component

Human PGC-1alpha transcriptional coactivator / PPARGC1A

Human PGC-1alpha transcriptional coactivator / PPARGC1A. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. PGC-1 mRNA expression is dramatically elevated on cold exposure in both brown fat and skeletal muscle, and PGC-1 greatly increases the transcriptional activity of PPARgamma and the thyroid hormone receptor on the UCP1 promoter.

    Human PGC-1alpha transcriptional coactivator / PPARGC1A → Transcriptional activity at the UCP1 promoter source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/9529258.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf", "start_char": 0, "end_char": 842, "text_sha256": "8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf"}
    experimental_model
    Cloning of PGC-1 from a brown fat cDNA library with ectopic expression in white adipose cells
    exposure
    Cold exposure of mice; ectopic PGC-1 expression
    limitations
    The founding description of the coactivator. Ectopic expression shows sufficiency in white fat cells; it does not establish the size of the contribution in vivo.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Mouse
    plain_language
    Cold turns on a coactivator that switches the heat gene on through two different receptors.
    primary_references
    [cold-p9529258] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. (1998). https://pubmed.ncbi.nlm.nih.gov/9529258/ DOI: 10.1016/s0092-8674(00)81410-5
    tissue_or_cell_type
    Brown fat and skeletal muscle

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 338–349

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cloning of PGC-1 from a brown fat cDNA library with ectopic expression in white adipose cells · source_derived_draft · unverified_draft

    ### cold-pgc1a-cold-induction PGC-1 mRNA expression is dramatically elevated on cold exposure in both brown fat and skeletal muscle, and PGC-1 greatly increases the transcriptional activity of PPARgamma and the thyroid hormone receptor on the UCP1 promoter. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Cold turns on a coactivator that switches the heat gene on through two different receptors. organism: Mouse tissue_or_cell_type: Brown fat and skeletal muscle experimental_model: Cloning of PGC-1 from a brown fat cDNA library with ectopic expression in white adipose cells limitations: The founding description of the coactivator. Ectopic expression shows sufficiency in white fat cells; it does not establish the size of the contribution in vivo. exposure: Cold exposure of mice; ectopic PGC-1 expression evidence_span: {"source_cache": "artifacts/cold-research/9529258.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf", "start_char": 0, "end_char": 842, "text_sha256": "8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf"} [cold-p9529258] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. (1998). https://pubmed.ncbi.nlm.nih.gov/9529258/ DOI: 10.1016/s0092-8674(00)81410-5
    Complete structured claim and evidence

  2. Ectopic expression of PGC-1 in white adipose cells activated expression of UCP1 and key mitochondrial enzymes of the respiratory chain, and increased cellular mitochondrial DNA content.

    Human PGC-1alpha transcriptional coactivator / PPARGC1A → Cellular mitochondrial DNA content source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/9529258.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf", "start_char": 0, "end_char": 842, "text_sha256": "8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf"}
    experimental_model
    Cloning of PGC-1 from a brown fat cDNA library with ectopic expression in white adipose cells
    exposure
    Cold exposure of mice; ectopic PGC-1 expression
    limitations
    The founding description of the coactivator. Ectopic expression shows sufficiency in white fat cells; it does not establish the size of the contribution in vivo.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Mouse
    plain_language
    The same switch builds more mitochondria to do the burning.
    primary_references
    [cold-p9529258] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. (1998). https://pubmed.ncbi.nlm.nih.gov/9529258/ DOI: 10.1016/s0092-8674(00)81410-5
    tissue_or_cell_type
    Brown fat and skeletal muscle

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 351–362

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cloning of PGC-1 from a brown fat cDNA library with ectopic expression in white adipose cells · source_derived_draft · unverified_draft

    ### cold-pgc1a-mitochondrial-biogenesis Ectopic expression of PGC-1 in white adipose cells activated expression of UCP1 and key mitochondrial enzymes of the respiratory chain, and increased cellular mitochondrial DNA content. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The same switch builds more mitochondria to do the burning. organism: Mouse tissue_or_cell_type: Brown fat and skeletal muscle experimental_model: Cloning of PGC-1 from a brown fat cDNA library with ectopic expression in white adipose cells limitations: The founding description of the coactivator. Ectopic expression shows sufficiency in white fat cells; it does not establish the size of the contribution in vivo. exposure: Cold exposure of mice; ectopic PGC-1 expression evidence_span: {"source_cache": "artifacts/cold-research/9529258.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf", "start_char": 0, "end_char": 842, "text_sha256": "8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf"} [cold-p9529258] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. (1998). https://pubmed.ncbi.nlm.nih.gov/9529258/ DOI: 10.1016/s0092-8674(00)81410-5
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards