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Ectopic expression shows sufficiency in white fat cells; it does not establish the size of the contribution in vivo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Cold turns on a coactivator that switches the heat gene on through two different receptors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p9529258] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. 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Ectopic expression shows sufficiency in white fat cells; it does not establish the size of the contribution in vivo.\nexposure: Cold exposure of mice; ectopic PGC-1 expression\nevidence_span: {\"source_cache\": \"artifacts/cold-research/9529258.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf\", \"start_char\": 0, \"end_char\": 842, \"text_sha256\": \"8986da918d7bde4d0314f51038ee3b1c6413042a1132bb6fbf55ceeb54e79ddf\"}\n[cold-p9529258] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. (1998). https://pubmed.ncbi.nlm.nih.gov/9529258/ DOI: 10.1016/s0092-8674(00)81410-5","model_system":"Cloning of PGC-1 from a brown fat cDNA library with ectopic expression in white adipose cells","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cold-p9529258] A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. 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