Component
The postsynaptic dendritic spine
The postsynaptic dendritic spine. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Diacylglycerol lipase-alpha was localised around the postsynaptic spine, placing the production site of 2-arachidonoylglycerol in close proximity to the presynaptic CB1 receptor.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/16672646.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dd4ddba9cf6987282758f17ce79c5624f9a3cc6c02044a4a45c0664ef6fd21c3", "start_char": 0, "end_char": 1832, "text_sha256": "dd4ddba9cf6987282758f17ce79c5624f9a3cc6c02044a4a45c0664ef6fd21c3"}
- experimental_model
- Immunoelectron microscopy localising diacylglycerol lipase-alpha
- exposure
- Subcellular localisation against presynaptic CB1
- limitations
- An anatomical result that makes the signalling geometry concrete: the enzyme that makes the messenger sits directly opposite the receptor.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Rodent
- plain_language
- The factory for the messenger sits directly across the synapse from its receptor.
- primary_references
- [thc-p16672646] Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. (2006). https://pubmed.ncbi.nlm.nih.gov/16672646/ DOI: 10.1523/jneurosci.0054-06.2006
- tissue_or_cell_type
- Postsynaptic spine
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 309–320
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Immunoelectron microscopy localising diacylglycerol lipase-alpha · source_derived_draft · unverified_draft
### thc-dagla-localisation Diacylglycerol lipase-alpha was localised around the postsynaptic spine, placing the production site of 2-arachidonoylglycerol in close proximity to the presynaptic CB1 receptor. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The factory for the messenger sits directly across the synapse from its receptor. organism: Rodent tissue_or_cell_type: Postsynaptic spine experimental_model: Immunoelectron microscopy localising diacylglycerol lipase-alpha limitations: An anatomical result that makes the signalling geometry concrete: the enzyme that makes the messenger sits directly opposite the receptor. exposure: Subcellular localisation against presynaptic CB1 evidence_span: {"source_cache": "artifacts/thc-research/16672646.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dd4ddba9cf6987282758f17ce79c5624f9a3cc6c02044a4a45c0664ef6fd21c3", "start_char": 0, "end_char": 1832, "text_sha256": "dd4ddba9cf6987282758f17ce79c5624f9a3cc6c02044a4a45c0664ef6fd21c3"} [thc-p16672646] Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. (2006). https://pubmed.ncbi.nlm.nih.gov/16672646/ DOI: 10.1523/jneurosci.0054-06.2006
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.