Component
Portal venous unmetabolized folic acid fraction
Fraction of dose-derived portal folate remaining chemically unchanged.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Fifteen minutes after oral labeled folic acid, 80 ± 12% of portal dose-derived folate remained unchanged in five evaluable TIPSS subjects among six dosed.
Experimental context and source evidence
- experimental_model
- Portal/peripheral isotope crossover in six TIPSS patients
- exposure
- 500 nmol oral isotope-labeled folic acid, about 220 micrograms
- limitations
- The sixth subject had no detectable labeled portal folate at 15 minutes; small liver-disease cohort and shunt-altered peripheral kinetics.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- Much folic acid reached the liver unchanged.
- primary_references
- [patanwala2014] Folic acid handling by the human gut: implications for food fortification and supplementation (2014). https://pubmed.ncbi.nlm.nih.gov/24944062/ DOI: 10.3945/ajcn.113.080507
- tissue_or_cell_type
- Hepatic portal blood
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 387–397
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Portal/peripheral isotope crossover in six TIPSS patients · source_derived_draft · unverified_draft
### folate-portal-folic-acid-unmodified Fifteen minutes after oral labeled folic acid, 80 ± 12% of portal dose-derived folate remained unchanged in five evaluable TIPSS subjects among six dosed. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Much folic acid reached the liver unchanged. organism: Homo sapiens tissue_or_cell_type: Hepatic portal blood experimental_model: Portal/peripheral isotope crossover in six TIPSS patients limitations: The sixth subject had no detectable labeled portal folate at 15 minutes; small liver-disease cohort and shunt-altered peripheral kinetics. exposure: 500 nmol oral isotope-labeled folic acid, about 220 micrograms [patanwala2014] Folic acid handling by the human gut: implications for food fortification and supplementation (2014). https://pubmed.ncbi.nlm.nih.gov/24944062/ DOI: 10.3945/ajcn.113.080507
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.